Glycochenodeoxycholic acid sodium salt Chemical Properties

Melting point:

160-170 °C

storage temp. 

room temp

solubility 

H₂O: 50 mg/mL, clear, faintly yellow

form 

Solid

color 

White to Pale Brown

Water Solubility 

H2O: 50mg/mL, clear, faintly yellow

BRN 

3847290

Stability:

Hygroscopic

InChI

InChI=1/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/s3

InChIKey

AAYACJGHNRIFCT-YQIULKNUNA-M

SMILES

[C@@]12([H])CC[C@H]([C@H](C)CCC(=O)NCC([O-])=O)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@@H](O)C[C@@]3([H])C[C@@H](O)[C@@]21[H].[Na+] |&1:0,4,5,16,20,22,26,29,32,34,r|

Safety Information

Safety Statements 

24/25

WGK Germany 

3

F 

3-10

HS Code 

29242990

MSDS

• Language:English Provider:SigmaAldrich

Glycochenodeoxycholic acid sodium salt Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

Glycochenodeoxycholic Acid Sodium Salt is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.

Uses

Sodium glycochenodeoxycholate has been used in a study to assess the repair of DNA damage induced by bile salts. It has also been used in a study to investigate enterotoxin production by Clostridium perfringens type A in the presence of human bile salts.

Definition

ChEBI: A bile acid salt that is the sodium salt of glycochenodeoxycholic acid.

Biological Activity

Glycochenodeoxycholate (GCDC) can induce hepatocyte apoptosis th at is partially mediated by Fas.

Purification Methods

Dissolve it in EtOH, filter it and concentrate it to crystallisation, and recrystallise from a little EtOH. It also recrystallises from EtOH/Et2O. [Beilstein 10 IV 1611.]

Glycochenodeoxycholic acid sodium salt(16564-43-5)Related Product Information

• Glycochenodeoxycholic Acid
• Glycochenodeoxycholic Acid-3-O-β-glucuronide Disodium Salt
• Glycochenodeoxycholic Acid 3-Sulfate DisodiuM Salt
• Glycine tert butyl ester hydrochloride
• Glycine ethyl ester hydrochloride
• Glycine methyl ester hydrochloride
• Glycinamide
• (3a,5b,7a)-24-[(carboxymethyl)amino]-7-hydroxy-24-oxocholan-3-yl b-D-glucopyranosiduronic acid
• SODIUM GLYCOCHOLATE HYDRATE, 98
• Sodium deoxycholate
• Sodium cholate
• Glycocholic acid
• GLYCOCHOLIC ACID SODIUM SALT
• Chenodeoxycholic acid
• CHENODEOXYCHOLIC ACID SODIUM
• Sodium tauroglycocholate
• Cholic acid
• SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9
• Sodium Glycochenodeoxycholate