Basic information Safety Supplier Related

SHU-9119

Basic information Safety Supplier Related

SHU-9119 Basic information

Product Name:
SHU-9119
Synonyms:
  • SHU-9119
  • [N-ACETYL-NLE4,ASP5,D-2'-NAL7,LYS10]-ALPHA-MSH (4-10) AMIDE, ASP5-LYS10, CYCLIC LACTAM
  • AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2
  • AC-NLE-ASP-HIS-D-2'-NAL-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM
  • AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG
  • AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2
  • (AC-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
  • AC-[NLE4, ASP5, D-2-NAL7, LYS10]-CYCLO-ALPHA-MSH AMIDE (4-10)
CAS:
168482-23-3
MF:
C54H71N15O9
MW:
1074.24
Mol File:
168482-23-3.mol
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SHU-9119 Chemical Properties

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O : 20 mg/mL (18.62 mM; Need ultrasonic)
form 
Powder
pka
13.00±0.70(Predicted)
Water Solubility 
Soluble to 0.20 mg/ml in water
Sequence
Ac-Nle-Asp-His-D-Nal-Arg-Trp-Lys-NH2(Chemical Bridge Asp2-Lys7)
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Safety Information

WGK Germany 
3
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SHU-9119 Usage And Synthesis

Description

SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R. In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling. Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.

storage

Store at -20°C

SHU-9119Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Email
sales@alabiochem.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
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SHU-9119(168482-23-3)Related Product Information