2-METHANESULFONYL-PYRIMIDINE Chemical Properties

Boiling point:

335.6±25.0 °C(Predicted)

Density 

1.344±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

-3.39±0.13(Predicted)

form 

solid

color 

Yellow

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2933599590

2-METHANESULFONYL-PYRIMIDINE Usage And Synthesis

Application

2-Methylsulfonylpyrimidine can be used as a pharmaceutical synthesis intermediate and an organic synthesis intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes.

Synthesis

2-Methylsulfonylpyrimidine was prepared as follows: a suspension of potassium carbonate (27.6 g, 0.2 mol) in a solution of 2-mercaptopyrimidine (0.1 mol) and methyl iodide (18.7 ml, 0.3 mol) in acetone (200 ml) was heated to reflux for a period of 3 hours. The reaction mixture was allowed to cool and then filtered followed by vacuum evaporation. Distillation of the mixture at a pressure of 0.01 mmHg gave 12.7 g of 2-methylthio-4,6-dimethylpyrimidine as a white solid. A portion of this solid (4.42 g, 28.7 mmol) was dissolved in dichloromethane (200 ml) and m-chloroperoxybenzoic acid (50%, 22.8 g, 66.0 mmol) was added in batches. The resulting mixture was stirred for 5 days and finally it was filtered and then evaporated under vacuum. Purification by rapid column chromatography on silica gel, using ether as eluent, gave 2-methylsulfonylpyrimidine as a white solid, m.pt., 81 ??C.

2-METHANESULFONYL-PYRIMIDINE(14161-09-2)Related Product Information

• 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
• 5-BROMO-2-METHANESULFONYL-PYRIMIDINE
• 2-Methylsulfonyl-4,6-dimethoxypyrimidine
• 5-Chloro-2-(methylsulfonyl)pyrimidine
• 2-[(4-CHLOROPHENYL)SULFONYL]-4-METHYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE
• 4-METHYL-2-(PHENYLSULFONYL)-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE
• 2-CHLOROBENZYL 4-METHYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDIN-2-YL SULFONE
• 4-METHYL-2-([3-(TRIFLUOROMETHYL)PHENYL]SULFONYL)-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE
• ETHYL 2-[(4-METHYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDIN-2-YL)SULFONYL]ACETATE
• 2-[(4-CHLOROBENZYL)SULFONYL]-4-(2,3-DIMETHYLPHENOXY)-5,6,7,8-TETRAHYDROQUINAZOLINE
• AKOS BBS-00001997
• 2-[(3-METHOXYPHENYL)SULFONYL]-4-METHYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE
• 2-[(4-FLUOROPHENYL)SULFONYL]-4-METHYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE
• 2-[(3-CHLOROPHENYL)SULFONYL]-4-METHYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE
• 2-(BENZYLSULFONYL)-4-METHYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE
• 4-METHYL-2-[(4-METHYLPHENYL)SULFONYL]-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE
• 2,4-DICHLOROPHENYL 4-METHYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDIN-2-YL SULFONE
• 2-[(4-BROMOPHENYL)SULFONYL]-4-METHYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE