FORTUNELLIN Chemical Properties

Melting point:

193-198°C

Boiling point:

888.7±65.0 °C(Predicted)

Density 

1.62±0.1 g/cm3(Predicted)

pka

6.10±0.40(Predicted)

form 

Solid

color 

Off-white to light yellow

FORTUNELLIN Usage And Synthesis

Description

Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.

Chemical Properties

Off-white to light yellow Solid

Uses

Fortunellin is a flavonoid that can be isolated from kumquat (Fortunella margarita) fruit. Studies have shown that Fortunellin inhibits LPS-induced inflammation and ROS production in H9C2 cells, and also prevents fructose-induced inflammation and oxidative stress by enhancing the AMPK/Nrf2 pathway. In addition, Fortunellin has a dual role in the prevention and treatment of coronaviral disease, with antiviral activity against SARS-CoV-2 and anti-inflammatory immunomodulatory capacity in the host.

Biological Functions

Fortunellin (acacetin 7-O-neohesperidoside) is a citrus flavonoid isolated from kumquat fruit. Kumquat extract has attracted much attention recently for its beneficial effects on human health, which include antitumor, antioxidant and anti-inflammatory characteristics . The beneficial effects of flavonoids on IBD have been confirmed in many studies. However, although fortunellin is the main flavonoid in kumquat, there is a lack of information on its alleviation of IBD.

Mechanism of action

Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. Fortunellin ameliorated colitis symptoms, including excessive inflammation and oxidative stress. Fortunellin decreased epithelial cell apoptosis through inhibiting PTEN expression in colitis. Fortunellin-induced downregulation of PTEN could be counteracted by miR-374a depletion. Moreover, knockdown of miR-374a in vivo partly inhibited the effects of fortunellin on rat colitis.

FORTUNELLIN(20633-93-6)Related Product Information

• Acacetin
• FORTUNELLIN(RG)
• FORTUNELLIN(P)
• FORTUNELLIN(REAGENT / STANDARD GRADE)
• RHOIFOLIN
• 1-(2,4-DIETHOXY-PHENYL)-ETHANONE
• 4'-FORMYLPHENYL-BETA-D-GLUCOPYRANOSIDE
• 3',5'-Dimethoxytricetin 7-O-β-D-glucopypranoside
• FORTUNELLIN
• 7-HYDROXYFLAVONE-BETA-D-GLUCOSIDE
• NEOHESPERIDOSE
• Neoisoliquiritin
• L-PICEIN