Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Chemical Properties

Melting point:

115-118°C

Boiling point:

367.6±42.0 °C(Predicted)

Density 

1.263±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

10.07±0.10(Predicted)

form 

Solid

color 

Cream

Safety Information

HazardClass 

IRRITANT

HS Code 

2933399990

Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Usage And Synthesis

Uses

Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

Sulfuric acid (15 mL) and toluene (100 mL) were added to a concentrated solution of 2-hydroxynicotinic acid (50 g) in methanol (500 mL). The reaction mixture was stirred at room temperature for 28 hours before a Dean-Stark reflux device was installed and the reaction solution was neutralized with aqueous potassium carbonate, followed by evaporation of the solvent. Saturated aqueous ammonium chloride and chloroform were added to the residue, the organic layer was separated and the aqueous layer was extracted with chloroform. The organic layers were combined, dried with anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to afford methyl 2-hydroxynicotinate (46 g, 84% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ: 3.92 (s, 3H), 6.45 (dd, J=7.3,6.4 Hz, 1H), 7.78 (dd, J=6.4,2.4 Hz, 1H). 8.29 (dd, J=7.3,2.4Hz, 1H).

References

[1] Patent: EP1477186, 2004, A1. Location in patent: Page/Page column 41
[2] Patent: EP1357111, 2003, A1. Location in patent: Page/Page column 59-60
[3] European Journal of Medicinal Chemistry, 2012, vol. 52, p. 284 - 294
[4] Patent: US2013/317059, 2013, A1. Location in patent: Paragraph 0404
[5] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0331

Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate(10128-91-3)Related Product Information

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• METHYL 5-CHLORO-2-OXO-1-[3-(TRIFLUOROMETHYL)BENZYL]-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
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• METHYL 1-(2-CHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
• METHYL 1-(3-CHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
• ETHYL 5-CYANO-6-ETHOXY-2-HYDROXYNICOTINATE