(+)METHAMPHETAMINE HYDROCHLORIDE Chemical Properties

Melting point:

166-168?C

alpha 

D25 +14 to +20°

Flash point:

9°C

storage temp. 

Controlled Substance, -20°C Freezer

EPA Substance Registry System

Methamphetamine hydrochloride (51-57-0)

Safety Information

Hazard Codes 

T,F

Risk Statements 

25-39/23/24/25-23/24/25-11

Safety Statements 

45-36/37-16

RIDADR 

3249

WGK Germany 

2

RTECS 

SH5455000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2939710000

Toxicity

LD50 i.p. in mice: 70 mg/kg (Lands)

(+)METHAMPHETAMINE HYDROCHLORIDE Usage And Synthesis

Description

(+)-Methamphetamine (Item No. 13997) is an analytical reference material categorized as an amphetamine. It is the more physiologically active isomer of (±)-methamphetamine and is both neurotoxic and frequently abused. Methamphetamine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Chemical Properties

Off-White Solid

Originator

Desoxyn ,Abbott Laboratories

Uses

A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity. Controlled substance (stimulant).

Definition

ChEBI: A hydrochloride having methamphetamine as the base component.

Manufacturing Process

2 Methods of prepearing of methamphetamine:
1. (-)-Ephedrin was reduced by hydrogenesation with hydrogen in the presence of Pt-C catalyst to give the (+)-N-α-dimethylphenethylamine (methamphetamine), melting point 172°-174°C.
2. Methamphetamine was obtained by the methylation of phenylisopropylamine.
To give methamphetamine hydrochloride the base methamphetamine was treated by eqimolar quantity of hydrochloric acid.

Therapeutic Function

Sympathomimetic, Central stimulant

General Description

Methamphetamine, (+)-1-phenyl-2-methylaminopropanehydrochloride desoxyephedrine hydrochloride (Desoxyn), isthe N-methyl analog of dextroamphetamine. It has moremarked central and less peripheral action than dextroamphetamine.It has a very high abuse potential, and by the intravenousroute, its salts are known as “speed.” The overallabuse problem presented by the drug is a national disaster.Medicinally acceptable uses of methamphetamine are analogousto those of dextroamphetamine.

Biochem/physiol Actions

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits toxic fumes of NOx and HCl. See also BENZEDRINE and various amphetamines.

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