4-FLUOROPHENYLGLYOXAL HYDRATE Chemical Properties

Melting point:

80 °C

Boiling point:

115 °C

Density 

1.411±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

solid

pka

10.51±0.41(Predicted)

color 

White

BRN 

2354778

CAS DataBase Reference

447-43-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RTECS 

CY1440000

HazardClass 

IRRITANT

HS Code 

2914790090

MSDS

• Language:English Provider:ALFA

4-FLUOROPHENYLGLYOXAL HYDRATE Usage And Synthesis

Synthesis

General procedure for the synthesis of hydrated 4-fluorobenzoylformaldehyde from 4-fluoroacetophenone: general method: a mixture of substrate (0.6 mmol) and bromoethylene (2a, 0.06 mmol) in DMSO (1.1 mL) was placed in an open-topped flask and heated in an oil bath (see Table 2 for specific temperatures and reaction times). After completion of the reaction (monitored by TLC), the reaction mixture was diluted with water (11 mL), treated with saturated NaCl solution and extracted with ethyl acetate (5 × 4 mL). Only in case of synthesis of arylglyoxal, the organic layer was additionally washed with Na2CO3 solution (0.12 mmol, dissolved in 2 mL of water), followed by saturated aqueous NaCl solution and dried with anhydrous Na2SO4. The extract was purified by column chromatography (eluent: petroleum ether/ethyl acetate gradient) to give pure product.

References

[1] Chinese Chemical Letters, 2013, vol. 24, # 12, p. 1118 - 1122
[2] Tetrahedron, 2011, vol. 67, # 41, p. 8000 - 8008
[3] Chemistry of Heterocyclic Compounds, 2018, vol. 54, # 1, p. 51 - 57
[4] Khim. Geterotsikl. Soedin., 2018, vol. 54, # 1, p. 51 - 57,7
[5] Journal of Organic Chemistry, 1952, vol. 17, p. 1425,1429

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