3,5-HEPTANEDIONE Chemical Properties

Melting point:

26.25°C (estimate)

Boiling point:

175-177 °C/754 mmHg (lit.)

Density 

0.946 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.456(lit.)

Flash point:

135 °F

storage temp. 

Inert atmosphere,Room Temperature

form 

Liquid

pka

9.63±0.10(Predicted)

color 

Clear colorless to yellow

BRN 

635979

CAS DataBase Reference

7424-54-6(CAS DataBase Reference)

EPA Substance Registry System

3,5-Heptanedione (7424-54-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25

RIDADR 

UN 1224 3/PG 3

WGK Germany 

3

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29141900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3,5-HEPTANEDIONE Usage And Synthesis

Chemical Properties

Clear colorless liquid

Uses

Enantioselective conjugate addition of 1,3-dicarbonyls to nitroolefins via nickel (II)-diamine catalysis.1

Uses

3,5-Heptanedione has been used in:

• preparation of 3,5-diethylpyrazole hydrochloride
• enantioselective conjugate addition of 1,3-dicarbonyls to nitroolefins via nickel(II)-diamine catalysis

Synthesis

Suspend 60 g of NaH (50% dispersed in mineral oil) in 200 mL of anhydrous benzene, heat to reflux and stir for 30 minutes. After cooling to 60°C, 2 mL of ethanol was slowly added dropwise. The reaction was continued for 2 hours after the dropwise addition was completed. Subsequently, a mixture of 2.5 mol of ethyl propionate and 1.0 mol of 2-butanone was added slowly dropwise to the reaction flask. After completion of the reaction, it was cooled to room temperature, 200 mL of water was added dropwise under nitrogen protection and the pH was adjusted to 7.0 with dilute hydrochloric acid. after standing and layering, the organic layer was separated and treated by adding 50 mL of acetic acid to it. The solvent was recovered by distillation under reduced pressure to obtain the crude 3,5-heptanedione. The crude product was dissolved in 200 mL of ethanol and a solution prepared from 55 g of copper chloride dissolved in 300 g of water was added to form a 3,5-heptanedione copper salt chelate. The blue chelate was collected by filtration, dissolved in 1000 mL of 20% sulfuric acid solution, and extracted three times with 500 mL of dichloromethane. The organic layers were combined, dried with anhydrous sodium sulfate, and the methylene chloride was recovered by distillation under reduced pressure to give a final 65.3 g of 3,5-heptanedione (boiling point: 174-175°C) with a purity of 97.3% (as determined by gas chromatography), and a yield of 49.6% as 2-butanedione.

References

[1] Patent: CN106810427, 2017, A. Location in patent: Paragraph 0019; 0020; 0021; 0022; 0023; 0024
[2] Patent: CN107867985, 2018, A. Location in patent: Paragraph 0019; 0020
[3] Journal of the American Chemical Society, 1950, vol. 72, p. 1352,1353, 1356
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972, p. 2623 - 2630

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