4-(TRIFLUOROACETYL)TOLUENE Chemical Properties

Melting point:

5°C

Boiling point:

70 °C

Density 

1.2304 g/cm3(Temp: 25 °C)

refractive index 

1.47

Flash point:

70-72°C/15mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

clear liquid

color 

Colorless to Light yellow to Light orange

BRN 

1870406

CAS DataBase Reference

394-59-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37

HazardClass 

IRRITANT

HS Code 

29039990

MSDS

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4-(TRIFLUOROACETYL)TOLUENE Usage And Synthesis

Chemical Properties

Clear colorless to light yellow liquid

Uses

p-Trifluoroacetyltoluene is used as a reagent in the synthesis of 5-methylene-2-(trifluoromethyl)morpholin-3-one derivatives which have fungicidal activity.

Synthesis

In a nitrogen atmosphere, one PTFE magnet was placed in a reactor, and 0.4 mmol p-methylbenzene diazonium tetrafluoroborate, 0.1 mmol cuprous oxide, 1 , 0.8 mmol dimethyl sulfoxide, and finally 1.2 mmol ethyl trifluoropyruvate were added. mL of dichloromethane, 0.8 mmol of dimethyl sulfoxide, and finally 1.2 mmol of ethyl trifluoropyruvate were added, and the reaction was stirred at 25 ??C for 16 in a closed system. After h, the reaction was extracted with ether 3 times, 10 mL each time, the organic phases were combined and washed with distilled water 3 times, the organic phase was dried with anhydrous magnesium sulfate, filtered, and then rotary evaporated to remove the organic solvent . The obtained crude product was eluted by silica gel column chromatography with n-pentane as eluent to obtain 4-(trifluoroacetyl)toluene (86% isolated yield).

4-(TRIFLUOROACETYL)TOLUENE(394-59-2)Related Product Information

• 4-(TRIFLUOROACETYL)TOLUENE
• 4-(TRIFLUOROACETYL)BENZOIC ACID
• 4'-Methylacetophenone
• Trifluoroacetophenone
• 4'-TERT-BUTYL-2,2,2-TRIFLUOROACETOPHENONE
• 1-(3-CHLORO-4-METHYL-PHENYL)-2,2,2-TRIFLUORO-ETHANONE
• 3'-FLUORO-4'-METHYL-2,2,2-TRIFLUOROACETOPHENONE
• Ethanone, 1-(3,4-dimethylphenyl)-2,2,2-trifluoro- (9CI)
• Ethanone, 2,2,2-trifluoro-1-(4-propylphenyl)- (9CI)
• 4'-N-BUTYL-2,2,2-TRIFLUOROACETOPHENONE
• Ethanone, 1-(2,4-dimethylphenyl)-2,2,2-trifluoro- (9CI)
• Ethanone, 2,2,2-trifluoro-1-[4-(1-methylethyl)phenyl]- (9CI)
• Ethanone, 1-(4-ethylphenyl)-2,2,2-trifluoro- (9CI)
• 4'-CYANO-2,2,2-TRIFLUOROACETOPHENONE
• 4-(TRIFLUOROMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE
• 1-(4-METHYLNAPHTHYL) TRIFLUOROMETHYL KETONE
• 2,2,2-TRIFLUORO-1-(4-PENTYL-PHENYL)-ETHANONE
• P-DECYL-A,A,A-TRIFLUOROACETOPHENONE