5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Basic information
- Product Name:
- 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
- Synonyms:
-
- SALOR-INT L252034-1EA
- RARECHEM AL BO 0714
- 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
- BUTTPARK 23\09-45
- 5-amino-1-(4-fluorophenyl)-4-pyrazolecarboxylic acid
- 5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole
- 5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole, 1-(5-Amino-4-carboxy-1H-pyrazol-1-yl)-4-fluorobenzene
- 5-Amino-1-(4-fluorophenyl)pyrazole-4-carboxylic Acid
- CAS:
- 187949-90-2
- MF:
- C10H8FN3O2
- MW:
- 221.19
- Mol File:
- 187949-90-2.mol
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Chemical Properties
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Solid
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Usage And Synthesis
Synthesis
138907-68-3
187949-90-2
mmol) in a solvent mixture of methanol (200 mL). The reaction mixture was heated to reflux for 17 h, followed by cooling to room temperature and filtration. The filtrate was acidified with 2 N HCl solution to pH=7. The precipitated solid was collected by filtration and dried under reduced pressure to afford the target compound 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid as a light yellow solid (18.64 g, 95% yield), which was used in subsequent reactions without further purification.
References
[1] Patent: WO2008/53136, 2008, A1. Location in patent: Page/Page column 36
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 20, p. 5032 - 5038
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 5, p. 1562 - 1575
[4] Patent: WO2008/74814, 2008, A1. Location in patent: Page/Page column 56
[5] Patent: WO2008/777, 2008, A2. Location in patent: Page/Page column 58-59
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACIDSupplier
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5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID(187949-90-2)Related Product Information
- 5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
- 1-(4-FLUOROPHENYL)-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
- ethyl 5-amino-3-cyclobutyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate
- ethyl 5-amino-1-(3-chloro-4-fluorophenyl)-3-cyclopentyl-1H-pyrazole-4-carboxylate
- BUTTPARK 34\09-39
- ethyl 5-amino-3-cyclopentyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate
- 5-(BOC-AMINO)-1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
- 5-(CBZ-AMINO)-1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
- 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- 5-AMINO-1-(2-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
- 3-AMINO-6-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)PYRAZOLO[3,4-D][1,3]OXAZIN-4(1H)-ONE
- ethyl 5-amino-1-(3-chloro-4-fluorophenyl)-3-cyclobutyl-1H-pyrazole-4-carboxylate
- ETHYL 5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
- 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
- 5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER