ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-21/22

Safety Statements 

26-36-36/37

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR Usage And Synthesis

Uses

Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse has been used in:

• western blotting
• immunoprecipitation
• immunocytochemistry
• immunohistochemical staining

Uses

Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse has been used in

• enzyme linked immunosorbent assay (ELISA)
• immunoprecipitation
• immunoaffinity
• immunohistochemistry
• western blotting

Uses

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

General Description

Monoclonal Anti-EGFR (mouse IgG1 isotype) is derived from the hybridoma 225 produced by the fusion of mouse myeloma cells (NS-1-503 cells) and splenocytes from BALB/c mice immunized with partially purified EGF receptors from A-431 cells. The receptor for epidermal growth factor (EGF) is an integral cell membrane glycoprotein of 170 kDa, which spans the membranes of a wide range of normal and malignant epithelial cells. The EGF receptor has an intracellular domain that exhibits tyrosine kinase activity.

Biochem/physiol Actions

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer.

ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR()Related Product Information

• Epidermal Growth Factor