GLYCOFUROL Chemical Properties

Boiling point:

100-145 °C0.4 mm Hg

Density 

1.09 g/mL at 25 °C(lit.)

vapor pressure 

4.97-37.4Pa at 20-50℃

refractive index 

n20/D 1.462(lit.)

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

Chloroform (Sparingly), Methanol (Slightly, Sonicated)

form 

Oil

color 

Colourless

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

LogP

-1.21--0.38

Safety Information

WGK Germany 

3

RTECS 

MD0907500

HS Code 

3907 20 20

MSDS

• Language:English Provider:SigmaAldrich

GLYCOFUROL Usage And Synthesis

Chemical Properties

Glycofurol is a clear, colorless, almost odorless liquid, with a bitter taste; it produces a warm sensation on the tongue.

Uses

Glycofurol is used as a carrier device for drug delivery.

Uses

Used as solvent to dissolve water-insoluble compounds.

Production Methods

Glycofurol is prepared by the reaction of tetrahydrofurfuryl alcohol with ethylene oxide (followed by a special purification process in the case of Glycofurol 75).

Pharmaceutical Applications

Glycofurol is used as a solvent in parenteral products for intravenous or intramuscular injection in concentrations up to 50% v/v. It has also been investigated, mainly in animal studies, for use as a penetration enhancer and solvent in topical and intranasal formulations. Glycofurol has also been used at 20% v/v concentration in a rectal formulation.

Safety

Glycofurol is mainly used as a solvent in parenteral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels used as a pharmaceutical excipient. Glycofurol can be irritant when used undiluted; its tolerability is approximately the same as propylene glycol.
Glycofurol may have an effect on liver function and may have a low potential for interaction with hepatoxins or those materials undergong extensive hepatic metabolism.
LD50 (mouse, IV): 3.5 mL/kg

storage

Stable if stored under nitrogen in a well-closed container protected from light, in a cool, dry place.

Incompatibilities

Incompatible with oxidizing agents.

Regulatory Status

Included in parenteral medicines licensed in Europe.

GLYCOFUROL(31692-85-0)Related Product Information

• Furfuryl alcohol
• Tetrahydrofurfuryl alcohol
• GLYCOFUROL,GLYCOFUROL TETRAGLYCOL
• NIERICINE NA-SALT
• cationomycin
• MONENSIN DECYL ESTER
• MONENSIN, [3H(G)]
• Monensin, 16-deethyl-3-O-demethyl-16-methyl-3-O-(1-oxopropyl)-
• SODIUM 4-[2-[5-ETHYL-5-[5-[6-HYDROXY-6-(HYDROXYMETHYL)-3,5-DIMETHYL-OXAN-2-YL]-3-METHYL-OXOLAN-2-YL]-OXOLAN-2-YL]-9-HYDROXY-2,8-DIMETHYL-1,6-DIOXASPIRO[4.5]DEC-7-YL]-3-METHOXY-2-METHYL-PENTANOATE
• Monensin
• NIGERICIN SODIUM SALT
• kijimicin
• AKOS NCG1-0012
• monensin methyl ester
• Monensin sodium salt
• GLYCOFUROL