NIGERICIN SODIUM SALT
NIGERICIN SODIUM SALT Basic information
- Product Name:
- NIGERICIN SODIUM SALT
- Synonyms:
-
- (2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid
- 28643-80-3 (Sodium salt)
- Aids003767
- Aids-003767
- Helix c
- AZALOMYCIN M
- HELIXIN C
- ANTIBIOTIC K178
- CAS:
- 28380-24-7
- MF:
- C40H68O11
- MW:
- 724.96
- Product Categories:
-
- antibiotic
- Mol File:
- 28380-24-7.mol
NIGERICIN SODIUM SALT Chemical Properties
- Melting point:
- 183.5-185°
- alpha
- D24 +36.2° (c = 0.842 in CHCl3)
- Boiling point:
- 779.9±60.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- chloroform: 10 mg/mL, clear, colorless
- pka
- 4.39±0.10(Predicted)
Safety Information
- Hazard Codes
- T,Xi
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-36/37/39-45-36
- RIDADR
- UN 3462 6.1/PG 3
- WGK Germany
- 3
- RTECS
- QT6840000
- F
- 10
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29419090
- Toxicity
- LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)
MSDS
- Language:English Provider:SigmaAldrich
NIGERICIN SODIUM SALT Usage And Synthesis
Uses
Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.
Definition
ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.
NIGERICIN SODIUM SALTSupplier
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- Sodium stearate
- Nigericin sodium salt
- 1,3,3-TRIMETHOXYBUTANE