NIGERICIN SODIUM SALT Chemical Properties

Melting point:

183.5-185°

alpha 

D24 +36.2° (c = 0.842 in CHCl3)

Boiling point:

779.9±60.0 °C(Predicted)

Density 

1.19±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

chloroform: 10 mg/mL, clear, colorless

pka

4.39±0.10(Predicted)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

25-36/37/38

Safety Statements 

26-36/37/39-45-36

RIDADR 

UN 3462 6.1/PG 3

WGK Germany 

3

RTECS 

QT6840000

F 

10

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29419090

Toxicity

LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)

MSDS

• Language:English Provider:SigmaAldrich

NIGERICIN SODIUM SALT Usage And Synthesis

Uses

Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.

Definition

ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.

NIGERICIN SODIUM SALT(28380-24-7)Related Product Information

• 1,16-HEXADECANEDIOL
• n-Octacosane
• NIGERICIN SODIUM SALT
• TRICOSANOIC ACID
• CAPRIC ACID SODIUM SALT
• N-NONACOSANE
• 1-TERT-BUTOXY-2-PROPANOL
• 3,6,9,12-tetraoxahexadecan-1-ol
• 11-HENEICOSANOL
• (R)-1,2-DODECANEDIOL
• 1-HEXACOSANOL
• 2-(OCTADECYLOXY)ETHANOL
• N-CAPROIC ACID SODIUM SALT
• TRI(PROPYLENE GLYCOL) PROPYL ETHER
• Dipropylene Glycol Dimethyl Ether
• Sodium stearate
• Nigericin sodium salt
• 1,3,3-TRIMETHOXYBUTANE