CAPRIC ACID SODIUM SALT Chemical Properties

Melting point:

~240 °C (dec.)

storage temp. 

2-8°C

solubility 

H₂O: 0.1 g/mL, clear, colorless

form 

powder to crystal

color 

White to Light yellow

Water Solubility 

very faint turbidity

BRN 

3572742

LogP

3.965 (est)

CAS DataBase Reference

1002-62-6(CAS DataBase Reference)

EPA Substance Registry System

Sodium decanoate (1002-62-6)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

HE0200000

HS Code 

2915.90.5050

MSDS

• Language:English Provider:SigmaAldrich

CAPRIC ACID SODIUM SALT Usage And Synthesis

Description

Decanoic acid is a medium-chain saturated fatty acid. It is a non-competitive antagonist at AMPA receptors that selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2 and GluA3 subunit-containing AMPA receptors (IC₅₀ = 0.52 mM) over those expressing GluA1 (IC₅₀ = 2.09 mM) or GluA1 and GluA2 subunits (IC₅₀ = 1.16 mM). It inhibits epileptiform activity induced by pentylenetetrazole or low magnesium in rat hippocampal slices. Decanoic acid (1 mM) induces contractions in isolated guinea pig duodenum, an effect that can be blocked by the muscarinic acetylcholine receptor antagonist hyoscine, voltage-gated sodium channel inhibitor tetrodotoxin (Item Nos. 14964 | 14963), or M₂ muscarinic acetylcholine receptor antagonist hexamethonium . It increases the escape threshold in an orofacial mechanical stimulation test in rats when administered at a topical dose of 30% in ointment form, indicating analgesic activity. This effect can be blocked by the muscarinic acetylcholine receptor antagonist methoctramine . Plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer.

Uses

Sodium Caprate is the sodium salt of capric acid. It functions as a binder, emulsifier, and anticaking agent.

Purification Methods

Neutralise sodium hydroxide by adding a slight excess of free decanoic acid and recovering the excess acid by Et2O extraction. The salt is recrystallised from the aqueous solution by adding pure acetone and repeating the steps several times, then drying the salt in an oven at ca 110o [Chaudhury & Awuwallia Trans Faraday Soc 77 3119 1981]. [Beilstein 2 IV 1041.]

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