ANTI-E2F-1 Chemical Properties

storage temp. 

−20°C

form 

buffered aqueous solution

biological source

rabbit

Safety Information

Hazard Codes 

Xn

Risk Statements 

21/22

Safety Statements 

36/37

WGK Germany 

3

Storage Class

10 - Combustible liquids

MSDS

• Language:English Provider:SigmaAldrich

ANTI-E2F-1 Usage And Synthesis

Uses

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. (provided by RefSeq)