4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE Chemical Properties

Melting point:

144-145℃ (hexane ethyl acetate )

Boiling point:

376.6±27.0 °C(Predicted)

Density 

1.338±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

4.43±0.10(Predicted)

color 

White to Yellow

CAS DataBase Reference

82632-77-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

HS Code 

2934.10.2000

HazardClass 

IRRITANT

4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE Usage And Synthesis

Synthesis

GENERAL METHOD: Thiourea (0.04 mol) and iodine (0.02 mol) were ground homogeneously in a mortar and subsequently mixed with 4-chloropropiophenone (0.02 mol). The reaction mixture was heated in a water bath at 70°C with intermittent stirring for 8 hours. Upon completion of the reaction, the solid product was ground to a fine powder and washed with ether to remove unreacted 4-chloropropiophenone. Next, it was washed with 5% aqueous sodium thiosulfate to remove residual iodine and finally with distilled water. The crude product was dissolved in hot water and hot filtered to remove insoluble impurities. Ammonia was slowly added to the filtrate until 2-amino-4-(4'-chlorophenyl)-5-methyl-1,3-thiazole precipitated completely. The precipitate was collected and recrystallized with ethanol to give purified crystals of the target compound [9].

References

[1] Asian Journal of Chemistry, 2017, vol. 29, # 12, p. 2794 - 2798
[2] Journal of the Indian Chemical Society, 1960, vol. 37, p. 427 - 428
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 313 - 317

4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE(82632-77-7)Related Product Information

• 4-(2-Bromo-3-chloro-phenyl)-5- methyl-thiazol-2-ylamine
• 4-(3-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE
• 5-Thiazoleacetic acid, 4-(4-chlorophenyl)-2-(((4-hydroxyphenyl)methyl) amino)-, methyl ester
• 4-(2,4-DICHLOROPHENYL)-5-METHYL-1,3-THIAZOL-2-AMINE HYDROBROMIDE
• 4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE
• SALOR-INT L122041-1EA
• 5-Thiazoleacetic acid, 4-(4-chlorophenyl)-2-(((4-(dimethylamino)phenyl )methyl)amino)-, methyl ester
• ART-CHEM-BB B014642
• 5-Thiazoleacetic acid, 4-(4-chlorophenyl)-2-((phenylmethyl)amino)-, me thyl ester
• METHYL 2-(2-AMINO-4-(4-CHLOROPHENYL)THIAZOL-5-YL)ACETATE
• 4-(2,4-Dichloro-phenyl)-5- methyl-thiazol-2-ylamine
• SALOR-INT L120332-1EA
• 5-Thiazoleacetic acid, 2-(o-chlorobenzylamino)-4-(p-chlorophenyl)-, me thyl ester
• [4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YL]-HYDRAZINE
• 5-Thiazoleacetic acid, 4-(4-chlorophenyl)-2-(((2-hydroxyphenyl)methyl) amino)-, methyl ester