Basic information Safety Supplier Related

SQUALESTATIN

Basic information Safety Supplier Related

SQUALESTATIN Basic information

Product Name:
SQUALESTATIN
Synonyms:
  • SQUALESTATIN
  • L-694,599
  • Zaragozic acid A trisodium salt
  • ZARAGOZIC ACID A SODIUM SALT
CAS:
144541-82-2
MF:
C35H47NaO14
MW:
714.74
Mol File:
Mol File
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SQUALESTATIN Chemical Properties

storage temp. 
-20°C
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Safety Information

WGK Germany 
3

MSDS

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SQUALESTATIN Usage And Synthesis

Uses

Zaragozic acid A trisodium salt is a potent inhibitor of squalene synthase.

Uses

Zaragozic acid A trisodium salt has been used as:

  • a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
  • a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
  • a cholesterol synthesis inhibitor in T cells

Biochem/physiol Actions

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

SQUALESTATINSupplier

Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Energy Chemical
Tel
021-58432009 400-005-6266
Email
marketing1@energy-chemical.com
Shanghai Universal Biotech Co.,Ltd
Tel
18768175414
Email
gaojun@univ-bio.com
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SQUALESTATIN(144541-82-2)Related Product Information