3-FLUOROPHENETHYL ALCOHOL Chemical Properties

Boiling point:

90 °C3 mm Hg(lit.)

Density 

1.125 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.509(lit.)

Flash point:

225 °F

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-21/22

Safety Statements 

36/37/39-26

WGK Germany 

3

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

3-FLUOROPHENETHYL ALCOHOL Usage And Synthesis

Synthesis

2-(3-Fluorophenyl)acetaldehyde was synthesized by oxidation reaction using 3-fluorophenethyl alcohol as starting material. The steps were as follows: 1. 3-Fluorophenyl ethanol was reacted with an oxidizing agent (e.g., PCC or Swern oxidizing reagent) in a suitable solvent at 0 °C to room temperature. 2. After completion of the reaction, the target product, 2-(3-fluorophenyl)acetaldehyde, was obtained by extraction and purification by column chromatography. This synthetic route is efficient and selective and is suitable for laboratory scale preparation.

References

[1] Patent: WO2008/36294, 2008, A2. Location in patent: Page/Page column 4; 6/8
[2] Patent: WO2008/42353, 2008, A1. Location in patent: Page/Page column 35; 41-42
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 779 - 797
[4] Patent: WO2012/97121, 2012, A2. Location in patent: Page/Page column 14
[5] Patent: WO2008/42353, 2008, A1. Location in patent: Page/Page column 35; 41-42

3-FLUOROPHENETHYL ALCOHOL(75321-89-0)Related Product Information

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