1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Chemical Properties

Melting point:

140-142 °C

Boiling point:

330℃

Density 

1.25

Flash point:

153℃

storage temp. 

2-8°C

pka

2.38±0.20(Predicted)

Appearance

White to off-white Solid

1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Usage And Synthesis

Synthesis

Step 3: 1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate (414.4 mg, 1.676 mmol) was dissolved in a 3:1 THF/MeOH solvent mixture (5.6 mL), and 2.0 M KOH aqueous solution (2.1 mL, 4.19 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the organic solvent was removed by distillation under reduced pressure. The residue was diluted with 20% isopropanol/dichloromethane (IPA/DCM) mixed solvent and subsequently acidified to pH 3 with 1.0 M aqueous HCl. The resulting mixture was extracted twice with 20% IPA/DCM mixed solvent, the organic phases were combined, washed twice with water, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid ( 352.8 mg, 90.3% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ= 13.80 (s, 1H), 3.69-3.54 (m, 3H), 3.36-3.32 (m, 1H), 2.43-2.24 (m, 2H), 1.40 (s, 9H).

References

[1] Patent: WO2013/20062, 2013, A1. Location in patent: Paragraph 00244
[2] Patent: WO2018/178041, 2018, A1. Location in patent: Page/Page column 116; 117

1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID(1001754-59-1)Related Product Information

• (R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid
• 1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(9H-fluoren-9-ylmethyl) ester
• (3S)-1-[(tert-butoxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic acid