BRD5648
BRD5648 Basic information
- Product Name:
- BRD5648
- Synonyms:
-
- BRD5648
- (R)-BRD0705
- compound,Glycogen synthase kinase 3,negative,Glycogen synthase kinase-3,BRD-5648,GSK-3,BRD5648,inhibit,BRD 5648,Inhibitor,(R)-enantiomer,control
- 5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-, (4R)-
- BRD5648, 10 mM in DMSO
- (4R)-4-Ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one
- CAS:
- 2056261-42-6
- MF:
- C20H23N3O
- MW:
- 321.42
- Mol File:
- 2056261-42-6.mol
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BRD5648 Chemical Properties
- Boiling point:
- 512.0±50.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- pka
- 14.82±0.60(Predicted)
- form
- Solid
- color
- Light yellow to khaki
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BRD5648 Usage And Synthesis
Description
BRD5648 is an inactive (R)-enantiomer of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor. It can be used for acute myeloid leukemia (AML).
Uses
BRD5648 ((R)-BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].
References
[1] Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. DOI:10.1126/scitranslmed.aam8460
BRD5648Supplier
BOC Sciences
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Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
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TargetMol Chemicals Inc.
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Wuhan chuang he chemical co. LTD
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