Ontuxizumab
Ontuxizumab Basic information
- Product Name:
- Ontuxizumab
- Synonyms:
-
- Ontuxizumab
- Research Grade Ontuxizumab (DHJ61001)
- MORAb-004
- Research Grade Ontuxizumab
- CAS:
- 946415-62-9
- MW:
- 0
- Mol File:
- Mol File
More
Less
Ontuxizumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
More
Less
Ontuxizumab Usage And Synthesis
Uses
Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer[1].
in vivo
Ontuxizumab (50 mg/kg; i.v., 5 doses daily for 5 consecutive days) shows antitumor effects in human CD248 knock-in mice[1].
| Animal Model: | Human CD248 knock-in mice[1] |
| Dosage: | 50 mg/kg |
| Administration: | Intravenous injection via tail vein; 50 mg/kg, 5 doses daily for 5 consecutive days |
| Result: | Reduced tumor growth with a lower level of CD248 and α-SMA on neovasculature pericytes. |
References
[1] Rybinski K, et al. Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature. Oncotarget. 2015 Sep 22;6(28):25429-40. DOI:10.18632/oncotarget.4559
OntuxizumabSupplier
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Guangzhou Hongyuan Chemical Co.,Ltd
- Tel
- 15817493340
- 981810490@qq.com
Wuhan Chemstan Biotechnology Co., Ltd.
- Tel
- 027-65317797 15926423062
- 422450190@qq.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com
Biolab Reagents
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com