AMBUPHYLLINE Chemical Properties

Melting point:

254-256°

Safety Information

Toxicity

LD50 i.v. in rabbits: 163 mg/kg; orally in mice: 600 mg/kg, (Thompson, Warren)

AMBUPHYLLINE Usage And Synthesis

Originator

Butaphyllamine,Merrell Dow,US,1944

Uses

Diuretic; relaxant (smooth muscle).

Manufacturing Process

Equimolecular proportions of theophylline and 2-amino-2-methyl-1-propanol are dissolved in water and the water is evaporated until crystallization is almost complete. The crystals are filtered off and dried. The product has a melting point of 254-256°C, softening at 245°C. It has a water solubility of about 55%. It may be compounded in the form of tablets, for oral administration, or may be prepared in solution for distribution in ampoules. For the manufacture of solutions for packaging in ampoules, it is more convenient to simply dissolve the theophylline and the butanolamine in water, without going through the intermediate step of separating the crystalline salt.

brand name

Butaphyllamine (Marion Merrell Dow).

Therapeutic Function

Diuretic, Smooth muscle relaxant

AMBUPHYLLINE(5634-34-4)Related Product Information

• Theophylline
• AMBUPHYLLINE
• Pamabrom