1H-Indole-4-carboxamide, 1-[6-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-4-pyrimidinyl]-2,3-dihydro-N-(2-hydroxyethyl)- Chemical Properties

Boiling point:

605.1±55.0 °C(Predicted)

Density 

1.388±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO : 50 mg/mL (108.60 mM; Need ultrasonic)

form 

Solid

pka

14.18±0.20(Predicted)

color 

Off-white to yellow

1H-Indole-4-carboxamide, 1-[6-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-4-pyrimidinyl]-2,3-dihydro-N-(2-hydroxyethyl)- Usage And Synthesis

Uses

PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). PW0787 suppresses psychostimulant behavior[1].

Biological Activity

PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). PW0787 suppresses psychostimulant behavior[1]. PW0787 (0.3, 1, 3, or 10 mg/kg; IP) displays antipsychotic-like activity by significantly inhibiting amphetamine-induced hyperlocomotor behavior in mice[1].PW0787 is evaluated in rats after a single dose of 20 mg/kg by oral (PO) or 10 mg/kg by intravenous (IV) administration. PW0787 has excellent plasma exposure after PO (AUC0-inf = 13,749 ng?h/mL) and IV dosing (AUC0-inf=9030 ng?h/mL), as well as high maximum serum concentration following PO (Cmax=3407 ng/mL) and IV administration (Cmax=6726 ng/mL). Additionally, PW0787 displays good volume of plasma distribution (Vss=1.5 L/kg) and acceptable plasma clearance (CL=1.1 L/h/kg) after 10 mg/kg IV. Excellent oral bioavailability (F) with the value of 76% is observed[1].

in vivo

References

[1]. Wang P, et al. Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior. J Med Chem. 2020;63(22):13951-13972.