1-benzyl-2,3-dimethylguanidinium sulphate (2:1) Chemical Properties

Melting point:

>262oC (dec.)

storage temp. 

Amber Vial, -20°C Freezer, Under inert atmosphere

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic, Light Sensitive

Safety Information

Toxicity

LD50 in mice (mg/kg): 12 i.v.; 150 i.p.; 260 s.c.; 520 by stomach intubation (Boura, Green)

1-benzyl-2,3-dimethylguanidinium sulphate (2:1) Usage And Synthesis

Originator

Bendogen,Lagap Pharmaceuticals SA

Uses

Antihypertensive.

Manufacturing Process

A mixture of 2-bromobenzylamine (12.5 g) and S-methylthiouronium sulfate (10 g) in water (20 ml) was heated for 1.5 hours on a steam bath in a hood, during which methylmercaptan escaped (as evidenced by a foul odour). The reaction mixture was then cooled and diluted with ethanol (100 ml). A colourless solid of 2-bromobenzylguanidine sulfate was separeted, and washed with ethanol. This solid melted at 230-232°C; it was recrystallized from water and then melted at 247-248°C. By action of a basic agent the salt obtained may be converted into free base.

brand name

Tenathan (Robins).

Therapeutic Function

Antihypertensive

Safety Profile

Poison by intraperitoneal,subcutaneous, and intravenous routes. Moderately toxicby ingestion. When heated todecomposition it emits toxic fumes of NOx and SOx.

Safety Profile

Poison by subcutaneous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits toxic fumes ofSOx and NOx.