8-Bromo-4-chromanone Chemical Properties

Boiling point:

339℃

Density 

1.621

Flash point:

159℃

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to light yellow Solid

8-Bromo-4-chromanone Usage And Synthesis

Uses

8-Bromo-4-dihydrochromone is an important intermediate, but its synthesis yield is low, it is difficult to synthesize, and its selling price is more than 20 times that of the similar product 6-bromo-3-dihydrochromone.

Synthesis

Step 3: Synthesis of 8-bromo-benzotetrahydropyran-4-one (P34c) Compound P34b (2.0 g, 8.15 mmol) was dissolved in ethylene glycol (20 mL) and heated to reflux for 4 hours. After completion of the reaction, the reaction mixture was cooled, poured into water and extracted twice with ether (Et2O). The organic layers were combined and washed sequentially with 1 M aqueous sodium hydroxide (NaOH) and saturated aqueous ammonium bicarbonate (NH4HCO3). The organic layers were dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated, and finally purified by column chromatography (eluent: petroleum ether/ethyl acetate = 50/1) to afford the target compound P34c (0.88 g, 48% yield) as a yellow solid.

References

[1] Patent: WO2012/139775, 2012, A1. Location in patent: Page/Page column 60-61

8-Bromo-4-chromanone(204377-88-8)Related Product Information

• 8-BROMOCHROMANE
• 8-bromochroman-4-amine hydrochloride
• 8-BROMOTHIOCHROMAN-4-ONE
• 8-broMo-3,4-dihydro-2H-chroMen-4-aMine
• 8-BROMOCHROMAN-4-OL
• Hydrogen bromide
• 6-Fluoro-4-chromanone
• 8-CHLORO-2,3-DIHYDRO-4H-CHROMEN-4-ONE
• 7-Chloro-4-chromanone
• 8-Fluoro-4-chromanone
• 6-Bromo-2,3-dihydro-4H-chromen-4-one
• 7-Fluoro-4-chromanone
• 7-bromochroman-4-one
• 6-CHLOROCHROMAN-4-ONE
• 6,8-dibromo-2,3-dihydrochromen-4-one
• 8-Bromo-4-chromanone