Vocacapsaicin
Vocacapsaicin Basic information
- Product Name:
- Vocacapsaicin
- Synonyms:
-
- 1-Piperidinecarboxylic acid, 2-[(methylamino)methyl]-, 2-methoxy-4-[[[(6E)-8-methyl-1-oxo-6-nonen-1-yl]amino]methyl]phenyl ester
- CA-008
- Vocacapsaicin
- CAS:
- 1931116-86-7
- MF:
- C26H41N3O4
- MW:
- 459.62
- Mol File:
- 1931116-86-7.mol
Vocacapsaicin Chemical Properties
- Boiling point:
- 632.9±55.0 °C(Predicted)
- Density
- 1.063±0.06 g/cm3(Predicted)
- pka
- 15.46±0.46(Predicted)
Vocacapsaicin Usage And Synthesis
Description
Vocacapsaicin (CA-008), a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief.
Mode of action
Vocacapsaicin(CA-008, Conentric Analgesics) – an investigational TRPV agonist being studied for long-lasting pain – works through the same TRPV1 agonism mechanism but its localized delivery is thought to minimize activation of a large array of neurons, such as capsaicin topical products.
References
[1] TARRA KNOTTS. Pharmacokinetics and local tissue response to local instillation of vocacapsaicin, a novel capsaicin prodrug, in rat and rabbit osteotomy models[J]. Journal of Orthopaedic Research?, 2022, 40 10: 2281-2293. DOI:10.1002/jor.25271.
[2]. Olivia Higgins, et al. Analgesics of the Future: The Potential of Vocacapsaicin Injections for Knee Pain. 12 Articles in Volume 21, Issue #2.