MELPERONE Chemical Properties

Melting point:

78.0 to 82.0 °C

Boiling point:

bp0.1 120-125°

Density 

1.046±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 41.67 mg/mL (158.23 mM)

pka

9.34±0.10(Predicted)

form 

powder to crystal

color 

White to Light yellow to Light orange

Merck 

14,5827

Safety Information

HS Code 

2933.39.3100

MELPERONE Usage And Synthesis

Originator

Eunerpan,Nordmark,W. Germany,1965

Definition

ChEBI: 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone is an aromatic ketone.

Manufacturing Process

A solution or dispersion consisting of 20.1 g (0.1 mol) of γ-chloro-pfluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine and 0.1 g of potassium iodide in 150 ml toluene is heated in a sealed glass tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation in vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125°C and at a pressure lower than 0.1 mm Hg is collected. The base is dissolved in ether and the 4-fluoro-γ-(4-methylpiperidino)-butyrophenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether.
Yield 22.0 g (73% of theory). MP 209°C to 211°C.

Therapeutic Function

Neuroleptic

MELPERONE(3575-80-2)Related Product Information

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