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Polyhexamethyleneguanidine phosphate

Basic information Safety Supplier Related

Polyhexamethyleneguanidine phosphate Basic information

Product Name:
Polyhexamethyleneguanidine phosphate
Synonyms:
  • POLYHEXAMETHYLENE GUANIDINE PHOSPHATE
  • PHMG phosphate
  • Poly(iminoimidocarbonyliminohexamethylene) phosphate
  • PHMG phosphate/ Polyhexamethyleneguanidine phosphate
  • PHMG-P
  • Polyhexamethyleneguanidine phosphate(25% in H20)
CAS:
89697-78-9
MF:
C21H45N9X2.3H3O4P
MW:
717.631
Mol File:
89697-78-9.mol
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Polyhexamethyleneguanidine phosphate Usage And Synthesis

Uses

Polyhexamethyleneguanidine phosphate (PHMG-P) has been widely used as a disinfectant because of its strong bactericidal activity and low toxicity.

Toxicity evaluation

Administration of PHMG-P induced proinflammatory cytokines elevation and infiltration of immune cells into the lungs. Histopathological analysis revealed a dose-dependent exacerbation of both inflammation and pulmonary fibrosis on day 14. PHMG-P also decreased the total cell number and the CD4+/CD8+ cell ratio in the thymus, with the histopathological examination indicating severe reduction of cortex and medulla. The mRNA levels of biomarkers associated with T cell development also decreased markedly. These findings suggest that exposure of lung tissue to PHMG-P leads to pulmonary inflammation and fibrosis as well as thymic atrophy.

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