Basic information Safety Supplier Related

CH 55

Basic information Safety Supplier Related

CH 55 Basic information

Product Name:
CH 55
Synonyms:
  • CH 55
  • 4-[(1E)-3-[3,5-BIS(1,1-DIMETHYLETHYL)PHENYL]-3-OXO-1-PROPENYL]BENZOIC ACID
  • 4-[(E)-3-(3,5-Di-tert-butylphenyl)-3-oxo-1-propenyl]benzoic acid
  • 4-[(E)-3-[3,5-Bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid
  • 4-[(E)-3-[3,5-Bis(tert-butyl)phenyl]-3-oxo-1-propenyl]benzoic acid
  • (E)-4-(3-(3,5-Bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)benzoic acid
  • Benzoic acid, 4-(3-(3,5-bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)-, (E)-
  • Benzoic acid, 4-[(1E)-3-[3,5-bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propen-1-yl]-
CAS:
110368-33-7
MF:
C24H28O3
MW:
364.48
Product Categories:
  • Intracellular receptor
Mol File:
110368-33-7.mol
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CH 55 Chemical Properties

Melting point:
202-203.5 °C
Boiling point:
509.5±50.0 °C(Predicted)
Density 
1.085±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 5 mg/ml
form 
A crystalline solid
pka
4.09±0.10(Predicted)
color 
White to light yellow
Stability:
Light Sensitive
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CH 55 Usage And Synthesis

Uses

CH 55 is a synthetic analog of retinoic acid which is an effective inhibitor of angiogenesis. Retinoids and their analogs are also promising agents for cancer chemoprevention and therapy.

Definition

ChEBI: 4-[3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid is a member of chalcones.

Biological Activity

Highly potent synthetic retinoid that has high affinity for RAR- α and RAR- β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC 50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC 50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC 50 = 1 nM).

storage

Store at RT

CH 55Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Email
sales@rechemscience.com
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CH 55(110368-33-7)Related Product Information