5-BROMO-2,3-DIAMINOFLUOROBENZENE Chemical Properties

Boiling point:

274.8±35.0 °C(Predicted)

Density 

1.792±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

form 

crystalline solid

pka

2.07±0.10(Predicted)

color 

Faint red to faint purple to light brown

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2921599090

5-BROMO-2,3-DIAMINOFLUOROBENZENE Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-bromo-3-fluorobenzene-1,2-diamine from 2-fluoro-4-bromo-6-nitroaniline: to a solution of 4-bromo-2-fluoro-6-nitroaniline (0.5 g, 2.1 mmol) in tetrahydrofuran (THF, 4.6 mL) was added ethanol (EtOH, 4.6 mL) and water (H2O, 1.5 mL), followed by addition of iron powder (0.6 g , 10.6 mmol) and ammonium chloride (0.17 g, 3.2 mmol). The reaction mixture was stirred at 95 °C for 22 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered through diatomaceous earth. The solid residue was washed with ethanol until the filtrate was colorless. The filtrates were combined, concentrated under reduced pressure, and the residue was dissolved in ethyl acetate (EtOAc), washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to give the title compound, 5-bromo-3-fluorobenzene-1,2-diamine (0.43 g, 99% yield), as a brown waxy solid.

References

[1] Patent: WO2012/83170, 2012, A1. Location in patent: Page/Page column 156-157
[2] Patent: WO2010/20363, 2010, A1. Location in patent: Page/Page column 116-117
[3] Patent: CN108314680, 2018, A. Location in patent: Paragraph 0472-0476

5-BROMO-2,3-DIAMINOFLUOROBENZENE(517920-69-3)Related Product Information

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