Zinc acetate Chemical Properties

Melting point:

83-86 °C

Boiling point:

908°C

Density 

1.84 g/mL at 25 °C (lit.)

vapor pressure 

0.001Pa at 25℃

Flash point:

12 °C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Methanol (Slightly), Water (Slightly)

pka

4.756[at 20 ℃]

form 

Powder

Specific Gravity

1.84

color 

Yellow to brown to gray-green

Water Solubility 

Soluble in water, alcohol, dilute mineral acids and alkalies.

Sensitive 

Hygroscopic

Merck 

14,10128

InChIKey

DJWUNCQRNNEAKC-UHFFFAOYSA-L

LogP

-1.28

CAS DataBase Reference

557-34-6(CAS DataBase Reference)

NIST Chemistry Reference

Zinc acetate(557-34-6)

EPA Substance Registry System

Zinc acetate (557-34-6)

Safety Information

Hazard Codes 

Xn,N,Xi,F

Risk Statements 

36-50/53-22-11

Safety Statements 

26-60-61-39-16-7

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

RTECS 

AK1500000

TSCA 

Yes

HazardClass 

9

HS Code 

29152990

Hazardous Substances Data

557-34-6(Hazardous Substances Data)

MSDS

• Language:English Provider:Zinc acetate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Zinc acetate Usage And Synthesis

Description

Zinc acetate (chemical formula: Zn(O2CCH3)2) is a kind of salt commonly existing in the dihydrate form. It appears as colorless solid. It is produced through the reaction between zinc oxide with acetate acid. Given that zinc is an essential element for growth and development of human body, zinc acetate can be used as a dietary supplement for the treatment of zinc deficiency. It plays an important role for the synthesis of cholesterol, protein, and fats. It can also be used as an astringent, styptic and emetic. In industry, it has various kinds of applications including wood preservation, manufacturing of other zinc salts as well as ethylene acetate, being used as a dye mordant, and analytical reagent.

Chemical Properties

Zinc acetate occurs as white crystalline, lustrous plates with a faint acetic odor and an astringent taste.

Physical properties

The acetate group is capable of binding to metal ions in a variety of ways through its two oxygen atoms and several connectivities are observed for the various hydrates of zinc acetate. Anhydrous zinc acetate adopts a polymeric structure consisting of zinc coordinated to four oxygen atoms in a tetrahedral environment, each tetrahedron being connected to neighbors by the acetate groups . The acetate ligands are not bidentate. In contrast, most metal diacetates feature metals in octahedral coordination with bidentate acetate groups. In zinc acetate dihydrate the zinc is octahedral, wherein both acetate groups are bidentate.
2 - 5 - Heating pad
Heating Zn(CH3CO2)2 in a vacuum results in loss of acetic anhydride, leaving a residue of ""basic zinc acetate,"" with the formula Zn4O(CH3CO2)6. This cluster compound has the tetrahedral structure shown below. This species closely resembles the corresponding beryllium compound, although it is slightly expanded with Zn-O distances ～1.97 vs ～1.63 Å for Be4O(OAc)6.

Uses

Zinc acetate anhydrous is used in the synthesis of layered Zn-arylphosphonates with potential application in sorption, ion exchange or catalysis. It is utilized in the ultrasonic preparation of zinc sulfide nanoparticles coated on silica particles. It is administered orally or parenterally as a nutritional supplement. It finds an application in the field of industries such as wood preservation, manufacturing other zinc salts, polymers, manufacture of ethylene acetate, as a dye mordant, and analytical reagent. It also acts as a plating inhibitor on primary water piping.

Preparation

Zinc acetate is prepared by the reaction of acetic acid with zinc oxide followed by crystallization (crystals of dihydrate obtained): ZnO + 2CH₃COOH → (CH₃COO)₂Zn + H₂O.

Definition

ChEBI: Zinc acetate is an acetate salt in which the cationic component is zinc(2+). It has a role as an astringent. It is a zinc molecular entity and an acetate salt.

Application

Dietary and medicinal applications
Zinc acetate is used as a dietary supplement and in lozenges used to treat the common cold. Zinc acetate alone is thought to be a more effective treatment than zinc gluconate. Zinc acetate can also be used to treat zinc deficiencies. As an oral daily supplement it is used to inhibit the body's absorption of copper as part of the treatment for Wilson's disease. Zinc acetate is also sold as an astringent in the form of an ointment, a topical lotion; or combined with an antibiotic such as erythromycin for the topical treatment of acne. Furthermore Zinc acetate is commonly sold as a topical anti-itch ointment.
Industrial applications
Industrial applications include wood preserving, manufacturing other zinc salts, polymers, manufacture of ethylene acetate, as a dye mordant, and analytical reagent. Zinc acetate is a precursor via a sol-gel route to the transparent semi conductor zinc oxide. Zinc acetate is also used for manufacturing glazers for painting on porcelain; as a reagent in testing for albumin, tannin, phosphate; as cross-linking agents for polymers; in tobacco smoke filters; and as a topical fungicide.

Production Methods

Zinc acetate is synthesized by reacting zinc oxide with glacial acetic acid, with subsequent crystallization, separation by centrifugation, and drying and milling of the crystals. No organic solvents are used during the synthesis.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Zinc acetate has been used as an excipient in a variety of pharmaceutical formulations including topical gels, lotions, and solutions, and subcutaneous injections. It has also been investigated for use in an oral controlled-release formulation for water-soluble drugs in combination with sodium alginate and xanthan gum.
Therapeutically, zinc acetate has been used in oral capsules for the treatment of Wilson’s disease. Zinc acetate has also been demonstrated to be effective as a spermicide in vaginal contraceptives.

Safety

Zinc acetate is used in topical pharmaceutical formulations and subcutaneous injections, where it is generally regarded as relatively nontoxic and nonirritant when used as an excipient. However, zinc acetate is poisonous by intravenous and intraperitoneal routes; it is also moderately toxic following oral consumption.
Zinc acetate:
LD50 (rat, oral): 2.510 g/kg
LD50 (mouse, IP): 0.057 g/kg

Veterinary Drugs and Treatments

Zinc sulfate is used systemically as a nutritional supplement in a variety of species. Oral zinc acetate has been shown to reduce copper toxicity in susceptible dog breeds (Bedlington Terriers, West Highland White Terriers) with hepatic copper toxicosis. Zinc therapy may also be of benefit in the treatment of hepatic fibrosis in the dog. Zinc sulfate is used topically as an astringent and as a weak antiseptic both for dermatologic and ophthalmic conditions.

storage

Zinc acetate loses water of hydration above 101℃. Zinc acetate should be stored in an airtight container in a cool, dry, place.

Incompatibilities

Zinc acetate is incompatible with oxidizing agents, zinc salts, alkalis and their carbonates, oxalates, phosphates, and sulfides.

Regulatory Status

Included in the FDA Inactive Ingredients Database (SC injections; topical lotions and solutions). Included in medicines licensed in the UK.

References

https://en.wikipedia.org/wiki/Zinc_acetate
https://pubchem.ncbi.nlm.nih.gov/compound/Zinc_acetate_dihydrate#section=GHS-Classification

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