5,8,11,14-Eicosatetraenoic-16,16,17,17,18,18,19,19,20,20,20-d11 acid, (5Z,8Z,11Z,14Z)- Chemical Properties

solubility 

0.1 M Na2CO3: 1.7 mg/ml
DMF: >100 mg/ml
DMSO: >100 mg/ml
Ethanol: Miscible

form 

Liquid

color 

Colorless to light yellow

5,8,11,14-Eicosatetraenoic-16,16,17,17,18,18,19,19,20,20,20-d11 acid, (5Z,8Z,11Z,14Z)- Usage And Synthesis

Description

Arachidonic acid-d₁₁ is intended for use as an internal standard for the quantification of arachidonic acid by GC- or LC-mass spectrometry. Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways.¹ Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-uptake of free arachidonate are all important aspects of cell signaling and inflammation.²

Arachidonic acid-d₁₁ MaxSpec^? standard is a quantitative grade standard of arachidonic acid-d₁₁ that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This arachidonic acid-d₁₁ MaxSpec^? standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

Arachidonic acid-d11 is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes[1][2].

References

[1] Nixon, A.B., Greene, D.G., and Wykle, R.L. Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils Biochim. Biophys. Acta 1300(3),187-196(1996).
[2] Burgoyne, R.D., and Morgan, A. The control of free arachidonic acid levels Trends Biochem. Sci. 15(10),365-366(1990).
[3] A. NIKOLAI VON KRUSENSTIERN. Identification of essential sites of lipid peroxidation in ferroptosis[J]. Nature chemical biology, 2023, 19 6: 719-730. DOI: 10.1038/s41589-022-01249-3
[4] FILIPPO VEGLIA. Fatty acid transport protein 2 reprograms neutrophils in cancer[J]. Nature, 2019, 569 7754: 73-78. DOI: 10.1038/s41586-019-1118-2

5,8,11,14-Eicosatetraenoic-16,16,17,17,18,18,19,19,20,20,20-d11 acid, (5Z,8Z,11Z,14Z)-(2692624-11-4)Related Product Information

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