Ambruticin
Ambruticin Basic information
- Product Name:
- Ambruticin
- Synonyms:
-
- Ambruticin
- (+)-ambruticin S
- L-gluco-Non-8-enonic acid, 3,7-anhydro-2,4,8,9-tetradeoxy-9-[(1S,2S,3R)-2-[(1E,3R,4E)-5-[(2R,6R)-6-ethyl-3,6-dihydro-5-methyl-2H-pyran-2-yl]-3-methyl-1,4-hexadien-1-yl]-3-methylcyclopropyl]-, (8E)-
- W 7783
- W7783
- W-7783
- CAS:
- 58857-02-6
- MF:
- C28H42O6
- MW:
- 474.634
- Mol File:
- 58857-02-6.mol
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Ambruticin Usage And Synthesis
Originator
Ambruticin,Universitet Karlsruhe (TH)
Uses
Antifungal.
Therapeutic Function
Antifungal
in vivo
The acute LD50 values for the sodium salt of Ambruticin in mice were: intravenous 315 mg/kg, oral > 1000 mg/kg[1].
Ambruticin is rapidly absorbed by the oral route in mice. Ambruticin (75 mg/kg, gavage) produces a peak serum level of 46 μg/mL with a serum half-life of 3.1 h[2].
Ambruticin (40 mg/kg, oral, twice daily for a total of 10 days) shows protective activity in Guinea pigs infected with a severe T. mentagrophytes challenge[2].
Ambruticin shows protective activity in mice acutely infected with a severe C. albicans challenge[2].
| Animal Model: | Guinea pigs (infected with a strain of T. mentagrophytes)[2] |
| Dosage: | 40 mg/kg |
| Administration: | Oral, starting on day 3 postinfection, twice daily for a total of 10 days |
| Result: | On postinfection day 15, the guinea pig mean lesion score was approximately 1.3; by postinfection day 27, all the lesions were essentially healed. |