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Flunoxaprofen

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Flunoxaprofen Basic information

Product Name:
Flunoxaprofen
Synonyms:
  • Flunoxaprofen
  • (S)-2-(4-Fluorophenyl)-α-methyl-5-benzoxazoleacetic acid
  • Priaxim
  • S-(+)-Flunoxaprofen
  • Flunoxaprofen USP/EP/BP
  • 5-Benzoxazoleacetic acid, 2-(4-fluorophenyl)-α-methyl-, (αS)-
CAS:
66934-18-7
MF:
C16H12FNO3
MW:
285.273
Mol File:
66934-18-7.mol
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Flunoxaprofen Chemical Properties

Melting point:
162-164°
alpha 
D20 +50° (c = 2% in DMF)
Boiling point:
419.4±30.0 °C(Predicted)
Density 
1.334±0.06 g/cm3(Predicted)
pka
4.36±0.30(Predicted)
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Safety Information

Toxicity
LD50 orally in mice: ~1200 mg/kg (Dunwell)
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Flunoxaprofen Usage And Synthesis

Description

Flunoxaprofen is an antiinflammatory related to now withdrawn benoxaprofen, reportedly useful in the treatment of rheumatoid arthritis, myositis, synovitis and osteoarthritis. Its major mechanism of action is reported to be lipoxygenase inhibition, thus enabling the control of inflammation with less severe gastric disturbances.

Originator

Ravizza (Italy)

Definition

ChEBI: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects.

brand name

Priaxim

FlunoxaprofenSupplier

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