(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Chemical Properties

Boiling point:

524.2±50.0 °C(Predicted)

Density 

1.036±0.06 g/cm3(Predicted)

storage temp. 

Store at -80°C,protect from light

solubility 

DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): > 1 mg/ml

pka

4.66±0.10(Predicted)

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Usage And Synthesis

Description

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB₄ is an initial metabolite of LTB₄ formed via the LTB₄ 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB₄, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB₄. 12-oxo-LTB₄ (EC₅₀ = 33 nM) is about 70-fold less potent than LTB₄ (EC₅₀ = 0.46 nM) at stimulating Ca²⁺ mobilization in human neutrophils. It is also significantly less potent than LTB₄ at stimulating neutrophil migration with EC₅₀ values of 170 and 2.7 nM for 12-oxo-LTB₄ and LTB₄, respectively.

Uses

12-oxo Leukotriene B4 in acetonitrile is a potent eicosanoid lipid mediators.

Definition

ChEBI: A long-chain fatty acid consisting of leukotriene B4 having a 12-keto group in place of the 12-hydroxy group.

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid(136696-10-1)Related Product Information

• (5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
• 2,4-HEPTADIEN-6-ONE