ADRENORPHIN
ADRENORPHIN Basic information
- Product Name:
- ADRENORPHIN
- Synonyms:
-
- H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2
- METORPHIN
- METORPHINAMIDE
- Adrenorphin(3TFA)
- METORPHAMIDE
- ADRENORPHIN
- ADRENORPHIN (BOVINE)
- TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2
- CAS:
- 88377-68-8
- MF:
- C44H69N15O9S
- MW:
- 984.18
- Product Categories:
-
- Peptide
- CancerBiology
- Mol File:
- 88377-68-8.mol
ADRENORPHIN Chemical Properties
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO
- pka
- 9.97±0.15(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2
MSDS
- Language:English Provider:SigmaAldrich
ADRENORPHIN Usage And Synthesis
Biological Activity
adrenorphin (metorphamide) is a potent inhibitor of nicotine-induced adrenaline and noradrenaline release with ic50 value of 10 μm [1].adrenorphin (metorphamide) is an endogenous, c-terminally amidated, opioid octapeptide (tyr-gly-gly-phe-met-arg-arg-val-nh2) that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain [2].adrenorphin (metorphamide) is selective nicotine-induced adrenaline and noradrenaline release inhibitor and has higher than 100-fold more potent than the reported nicotine-induced adrenaline and noradrenaline release inhibitor met5-enkephalin. when tested with bovine adrenal chromaffin cells, adrenorphin (metorphamide) showed inhibition on 5 μm nicotine-induced atp release by almost 50% at 5μm and the inhibition was not in a dose-dependent manner [1]. in bioassays and binding assays, metorphamide exhibited high μ-binding activity, as well as κ-binding activity with nearly half percent toμ-binding activity, while showed no activity on δ-binding [2].
References
[1]. marley, p.d., k.i. mitchelhill, and b.g. livett, metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells. brain res, 1986. 363(1): p. 10-7.
[2]. weber, e., et al., metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. proc natl acad sci u s a, 1983. 80(23): p. 7362-6.
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ADRENORPHIN(88377-68-8)Related Product Information
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- MERGL
- LEU-ENKEPHALIN-ARG
- MET-ENKEPHALIN-ARG-ARG
- H-TYR-LYS-GLY-ARG-CYCLO(-GLU-TYR-ILE-LYS)-LEU-ILE-THR-ARG-PRO-ARG-TYR-NH2
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- ADRENORPHIN
- BAM 18P
- PEPTIDE E
- BAM-12P
- BAM-22P
- TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY
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