Win 54954
Win 54954 Basic information
- Product Name:
- Win 54954
- Synonyms:
-
- Win 54954
- 5-[5-[2,6-Dichloro-4-[(4,5-dihydrooxazol)-2-yl]phenoxy]pentyl]-3-methylisoxazole
- 5-{5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl}-3-methylisoxazole
- Isoxazole, 5-[5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl]-3-methyl-
- CAS:
- 107355-45-3
- MF:
- C18H20Cl2N2O3
- MW:
- 383.27
- Mol File:
- 107355-45-3.mol
Win 54954 Chemical Properties
- Boiling point:
- 555.4±50.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 100 mg/mL (260.91 mM; Need ultrasonic)
- form
- Solid
- pka
- 3.77±0.50(Predicted)
- color
- White to off-white
Win 54954 Usage And Synthesis
Uses
WIN 54954 is an orally active and broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections[1][2].
Definition
ChEBI: WIN54954 is an aromatic ether.
in vivo
WIN 54954 (2-100 mg/kg; p.o.) protects 50% of the mice from developing paralysis following infection with coxsackievirus A-9 and echovirus-9 at the dose of 2 and 100 mg/kg, respectively[1].
References
[1] Woods MG, et, al. In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug. Antimicrob Agents Chemother. 1989 Dec;33(12):2069-74. DOI:10.1128/AAC.33.12.2069
[2] Fechner H, et, al. Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections. Molecules. 2011 Oct 11;16(10):8475-503. DOI:10.3390/molecules16108475
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