butyryl timolol Chemical Properties

Boiling point:

511.5±50.0 °C(Predicted)

Density 

1.169±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

pka

8.74±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

butyryl timolol Usage And Synthesis

Uses

Butyryltimolol, an effective precursor of Timolol, improves the corneal penetration of Timolol[1]. Butyryltimolol is a β-adrenergic blocker[2].

IC 50

β adrenergic receptor

References

[1] Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69. DOI:10.1016/s0014-4835(88)80093-9
[2] Potter DE, et al. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9. DOI:10.3109/02713688809033206

butyryl timolol(106351-79-5)Related Product Information

• Timolol