insulin like-growth factor-binding protein-7 Chemical Properties

storage temp. 

-20°C

form 

lyophilized

color 

white to off-white

biological source

human

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

insulin like-growth factor-binding protein-7 Usage And Synthesis

Uses

IGFBP7 (insulin-like growth factor-binding protein 7) is from the IGFBP superfamily and is widely expressed in tissues. It contains 11 cysteines, a heparin-binding site, a Kazal-type trypsin inhibitor domain and a carboxyl-terminal immunoglobulin-like type C repeat. The IGFBP7 gene is mapped to human chromosome 4q12.

Biological Activity

IGFBP7 (insulin-like growth factor-binding protein 7) works as a tumor suppressor as well as an oncogene by controlling cell proliferation, cell attachment, apoptosis and angiogenesis. It is also involved in TGFβ (transforming growth factor β) signal pathway. IGFBP7 also interferes with the insulin pathway and is associated with the development of diabetes as well as cardiovascular diseases.IGFBP7 binds weakly to IGFs (insulin like growth factors) and strongly to insulin. It mainly participates in IGF-independent pathways.

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