Atibeprone
Atibeprone Basic information
- Product Name:
- Atibeprone
- Synonyms:
-
- Atibeprone
- 2H-1-Benzopyran-2-one, 3,4-dimethyl-7-[[5-(1-methylethyl)-1,3,4-thiadiazol-2-yl]methoxy]-
- CAS:
- 153420-96-3
- MF:
- C17H18N2O3S
- MW:
- 330.4
- Mol File:
- 153420-96-3.mol
More
Less
Atibeprone Usage And Synthesis
Originator
Atibeprone,BASF
Manufacturing Process
10 mmol of 7-methoxy-3,4-dimethylcoumarin were stirred with 10 mmol (4.04 g) of Lawesson's reagent (2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4- diphosphetane 2,4-disulfide) in 20 ml of toluene at 90°C for 1-2.5 h. After cooling, the solvent was distilled off, the residue was taken up in DMF, and water was added. The precipitate was filtered off with suction and the crude 3,4-dimethyl-7-(2-isopropyl-1,3,4-thiadiazol-5-ylmethoxy)-2-thiocoumarin was purified by recrystallization from methanol or by column chromatography (silica gel, methylene chloride). Yield: 98%, melting point: 134-135°C.
Therapeutic Function
Antidepressant