Becaplermin
Becaplermin Basic information
- Product Name:
- Becaplermin
- Synonyms:
-
- Becaplermin
- Regranex
- RWJ 60235
- CAS:
- 165101-51-9
- MW:
- 0
- Mol File:
- Mol File
Becaplermin Usage And Synthesis
Uses
Chronic dermal ulcers treatment (promotes the proliferation of mesenchymally-derived cells).
Indications
Becaplermin (Regranex) is a recombinant human platelet–derived growth factor (rhPDGF-BB) which is thought to enhance wound healing by stimulating granulation tissue. It is approved for the treatment of lower extremity neuropathic ulcers extending to the subcutaneous tissue in diabetic patients with an adequate blood supply. Local irritant reactions (erythema, burning, pain) occur in a minority of patients.
brand name
Regranex (Johnson & Johnson).
Clinical Use
Becaplermin, Regranex Gel, an endogenous polypeptidethat is released from cells that are involved in the healingprocess, is a recombinant human platelet–derived growthfactor (rhPDGF-BB). It is a growth factor that activates cell proliferation,differentiation, and function, and it is released from cells involvedin the healing process.Becaplermin is formulated as a gel recommended fortopical use in the treatment of ulcerations of the skin secondaryto diabetes.