Pyridine-3-sulfonyl chloride hydrochloride Chemical Properties

Melting point:

120-126

Flash point:

>110℃

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

Appearance

white solid

Water Solubility 

Reacts with water.

Sensitive 

Moisture Sensitive

Safety Information

Hazard Codes 

C

Risk Statements 

14-29-34

Safety Statements 

8-22-26-30-45-36/37/39

RIDADR 

UN 3265 8 / PGII

Hazard Note 

Corrosive/Keep Cold under -20C

HazardClass 

IRRITANT

HazardClass 

8

HS Code 

29333990

Pyridine-3-sulfonyl chloride hydrochloride Usage And Synthesis

Chemical Properties

White solid

Synthesis

General procedure for the synthesis of pyridine-3-sulfonyl chloride hydrochloride from 3-pyridinesulfonic acid: 3-pyridinesulfonic acid (3.00 g, 18.8 mmol) was mixed with phosphorus pentachloride (PCl5, 4.79 g, 23.0 mmol) in phosphorus oxychloride (POCl3, 6 mL). The reaction mixture was stirred and reacted at 120°C overnight (15 h). After completion of the reaction, it was cooled to room temperature, diluted with chloroform (CHCl3, 20 mL) and saturated with hydrogen chloride gas (HCl(g)). The precipitated white precipitate was collected by filtration, washed with chloroform and dried under reduced pressure to give the title compound pyridine-3-sulfonyl chloride hydrochloride (3.36 g, 83% yield) as a white powder.

References

[1] Advanced Synthesis and Catalysis, 2004, vol. 346, # 8, p. 925 - 928
[2] Patent: WO2008/3703, 2008, A1. Location in patent: Page/Page column 82
[3] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 24
[4] Patent: WO2006/36024, 2006, A1. Location in patent: Page/Page column 160
[5] Patent: EP2336107, 2015, B1. Location in patent: Paragraph 0306

Pyridine-3-sulfonyl chloride hydrochloride(42899-76-3)Related Product Information

• Pyridine-2,4,6-tricarboxylic acid
• PYRIDINE-2-CARBOXAMIDE
• PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
• PYRIDINE-3-SULFONIC ACID SODIUM SALT
• PYRIDINE-2,4-DICARBONITRILE
• 6-CHLORO-PYRIDINE-3-SULFONYL CHLORIDE
• 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride
• PYRIDINE-2-SULFONYL CHLORIDE HYDROCHLORIDE
• (6-FLUORO-4H-1,3-BENZODIOXIN-8-YL)METHYLAMINE HYDROCHLORIDE
• 5-NITRO-PYRIDINE-2-SULFONYL CHLORIDE
• 5-(Trifluoromethyl)pyridine-2-sulfonyl Chloride
• 5-BROMO-PYRIDINE-2-SULFONYL CHLORIDE
• 5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE
• 6-MORPHOLIN-4-YL-PYRIDINE-3-SULFONYL CHLORIDE
• pyridine-3-sulfonyl chloride
• 4-METHYL-PYRIDINE-2-SULFONYL CHLORIDE
• PYRIDINE-4-SULFONYL CHLORIDE
• PYRIDINE-2-SULFONYL CHLORIDE