(+/-)-15-HYDROXY-11Z,13E-EICOSADIENOIC ACID Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml

(+/-)-15-HYDROXY-11Z,13E-EICOSADIENOIC ACID Usage And Synthesis

Uses

(±)15-HEDE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE. 15-HEDE is formed from eicosadienoic acid in macrophages. It inhibits 5-lipoxygenase (5-LO; IC50=35 μM).

Definition

ChEBI: 15-HEDE is a hydroxyeicosadienoic acid that consists of 11Z,13E-eicosatrienoic acid bearing a 15-hydroxy substituent. It is produced by non-enzymatic oxidation of 11,14-eicosadienoic acid. There are no reports in the literature of biological activity associated with 15-HEDE. It has a role as a metabolite.

References

[1] Haviv, et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J. Med. Chem. 30(2), 254-263 (1987).

(+/-)-15-HYDROXY-11Z,13E-EICOSADIENOIC ACID(77159-57-0)Related Product Information

• 15(S)-HEDE
• 15(S)-HEDE [1-14C]
• 15(S)-HPEDE
• 13(S)-HODE-D4
• 15(R)-HEDE
• (+/-)-15-HYDROXY-11Z,13E-EICOSADIENOIC ACID