4-(BENZYLOXY)-PHENACYL BROMIDE Chemical Properties

Melting point:

91 °C

Boiling point:

419.5±25.0 °C(Predicted)

Density 

1.394±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Pale Beige

Stability:

Moisture Sensitive

4-(BENZYLOXY)-PHENACYL BROMIDE Usage And Synthesis

Uses

1-(4-(Benzyloxy)phenyl)-2-bromoethanone is an intermediate of Ractopamine Dimer Ether Dihydrochloride (R071420), which is an impurity of Ractopamine (R071400). A b-Adrenergic agonist. A repartitioning agent.

Preparation

Obtained by reaction of bromine with 4-benzyloxyacetophenone in methanol in the presence of concentrated hydrochloric acid at 0–5° for 1 h, then at r.t. for another 1 h (90%).

Synthesis

General procedure for the synthesis of 2-bromo-4'-benzyloxyacetophenone from 1-(4-(benzyloxy)phenyl)ethanone: To a clarified solution of 1-(4-(benzyloxy)phenyl)ethanone (16.1 g, 71.2 mmol) in tetrahydrofuran (200 mL) at 0 °C, slowly add phenyltrimethylammonium tribromide (29.4 g, 78 mmol) dropwise to a tetrahydrofuran ( 150mL) solution. After completion of the reaction, the insoluble material was removed by filtration and washed with tetrahydrofuran. The filtrate was concentrated and the resulting yellow oil was purified by recrystallization from isopropanol. The final product was 2-bromo-4'-benzyloxyacetophenone with a yield of 17.99 g and 83%.

References

[1] Advanced Synthesis and Catalysis, 2018, vol. 360, # 7, p. 1376 - 1383
[2] Journal of the Indian Chemical Society, 2002, vol. 79, # 5, p. 469 - 471
[3] Patent: WO2015/16728, 2015, A1. Location in patent: Page/Page column 36; 37; 62
[4] Australian Journal of Chemistry, 2008, vol. 61, # 12, p. 991 - 999
[5] Marine Drugs, 2012, vol. 10, # 6, p. 1412 - 1421

4-(BENZYLOXY)-PHENACYL BROMIDE(4254-67-5)Related Product Information

• 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
• 4-(9-ANTHROYLOXY)PHENACYL BROMIDE
• 5-BROMOACETYL-2-BENSYLOXYBENZOIC ACID METHYL ESTER
• 4'-Benzyloxy-2-bromopropiophenone
• 4-(BENZYLOXY)-PHENACYL BROMIDE
• 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone