4-(BENZYLOXY)-PHENACYL BROMIDE

Product Name: 4-(BENZYLOXY)-PHENACYL BROMIDE
CAS No.: 4254-67-5
Chemical Name: 4-(BENZYLOXY)-PHENACYL BROMIDE
Synonyms: 4-(BENZYLOXY)-PHENACYL BROMIDE;2-Bromo-4'-benzyloxyacetophenon;4'-Benzyloxy-α-bromoacetophenone;4'-(Benzyloxy)-α-bromoacetophenone;α-Bromo-4'-(benzyloxy)acetophenone;1-(Benzyloxy)-4-(bromoacetyl)benzene;1-(Bromoacetyl)-4-(benzyloxy)benzene;1-(4-(Benzyloxy)phenyl)-2-bromoethane;2-bromo-1-(4-benzyloxyphenyl)-1-ethanone;2-broMo-1-(4-phenylMethoxyphenyl)ethanone
CBNumber: CB8162779
Molecular Formula: C15H13BrO2
Formula Weight: 305.17
MOL File: 4254-67-5.mol

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4-(BENZYLOXY)-PHENACYL BROMIDE Property

Melting point:: 91 °C
Boiling point:: 419.5±25.0 °C(Predicted)
Density: 1.394±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Pale Beige
Stability:: Moisture Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B288010
Product name: 1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Packaging: 5g
Price: $435
Updated: 2021/12/16

AK Scientific

Product number: 5878AB
Product name: 1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Packaging: 250mg
Price: $135
Updated: 2021/12/16

Ambeed

Product number: A168007
Product name: 1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Purity: 98%
Packaging: 100mg
Price: $29
Updated: 2021/12/16

Ambeed

Product number: A168007
Product name: 1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Purity: 98%
Packaging: 250mg
Price: $58
Updated: 2021/12/16

Ambeed

Product number: A168007
Product name: 1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Purity: 98%
Packaging: 1g
Price: $107
Updated: 2021/12/16

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4-(BENZYLOXY)-PHENACYL BROMIDE Chemical Properties,Usage,Production

Uses

1-(4-(Benzyloxy)phenyl)-2-bromoethanone is an intermediate of Ractopamine Dimer Ether Dihydrochloride (R071420), which is an impurity of Ractopamine (R071400). A b-Adrenergic agonist. A repartitioning agent.

Preparation

Obtained by reaction of bromine with 4-benzyloxyacetophenone in methanol in the presence of concentrated hydrochloric acid at 0–5° for 1 h, then at r.t. for another 1 h (90%).

Synthesis

54696-05-8

4254-67-5

General procedure for the synthesis of 2-bromo-4'-benzyloxyacetophenone from 1-(4-(benzyloxy)phenyl)ethanone: To a clarified solution of 1-(4-(benzyloxy)phenyl)ethanone (16.1 g, 71.2 mmol) in tetrahydrofuran (200 mL) at 0 °C, slowly add phenyltrimethylammonium tribromide (29.4 g, 78 mmol) dropwise to a tetrahydrofuran ( 150mL) solution. After completion of the reaction, the insoluble material was removed by filtration and washed with tetrahydrofuran. The filtrate was concentrated and the resulting yellow oil was purified by recrystallization from isopropanol. The final product was 2-bromo-4'-benzyloxyacetophenone with a yield of 17.99 g and 83%.

References

[1] Advanced Synthesis and Catalysis, 2018, vol. 360, # 7, p. 1376 - 1383
[2] Journal of the Indian Chemical Society, 2002, vol. 79, # 5, p. 469 - 471
[3] Patent: WO2015/16728, 2015, A1. Location in patent: Page/Page column 36; 37; 62
[4] Australian Journal of Chemistry, 2008, vol. 61, # 12, p. 991 - 999
[5] Marine Drugs, 2012, vol. 10, # 6, p. 1412 - 1421

4-(BENZYLOXY)-PHENACYL BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(BENZYLOXY)-PHENACYL BROMIDE Suppliers

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4254-67-5, 4-(BENZYLOXY)-PHENACYL BROMIDERelated Search:

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline 4-(9-ANTHROYLOXY)PHENACYL BROMIDE 5-BROMOACETYL-2-BENSYLOXYBENZOIC ACID METHYL ESTER 4'-Benzyloxy-2-bromopropiophenone 4-(BENZYLOXY)-PHENACYL BROMIDE 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

4-(BENZYLOXY)-PHENACYL BROMIDE

2-broMo-1-(4-phenylMethoxyphenyl)ethanone

2-Bromo-4'-benzyloxyacetophenon

1-(Bromoacetyl)-4-(benzyloxy)benzene

4'-(Benzyloxy)-α-bromoacetophenone

4'-Benzyloxy-α-bromoacetophenone

α-Bromo-4'-(benzyloxy)acetophenone

1-(4-(Benzyloxy)phenyl)-2-bromoethane

Ethanone, 2-bromo-1-[4-(phenylmethoxy)phenyl]-

1-(Benzyloxy)-4-(bromoacetyl)benzene

2-bromo-1-(4-benzyloxyphenyl)-1-ethanone

4254-67-5