ChemicalBook > CAS DataBase List > 4-(BENZYLOXY)-PHENACYL BROMIDE

4-(BENZYLOXY)-PHENACYL BROMIDE

Product Name
4-(BENZYLOXY)-PHENACYL BROMIDE
CAS No.
4254-67-5
Chemical Name
4-(BENZYLOXY)-PHENACYL BROMIDE
Synonyms
4-(BENZYLOXY)-PHENACYL BROMIDE;2-Bromo-4'-benzyloxyacetophenon;4'-Benzyloxy-α-bromoacetophenone;4'-(Benzyloxy)-α-bromoacetophenone;α-Bromo-4'-(benzyloxy)acetophenone;1-(Benzyloxy)-4-(bromoacetyl)benzene;1-(Bromoacetyl)-4-(benzyloxy)benzene;1-(4-(Benzyloxy)phenyl)-2-bromoethane;2-bromo-1-(4-benzyloxyphenyl)-1-ethanone;2-broMo-1-(4-phenylMethoxyphenyl)ethanone
CBNumber
CB8162779
Molecular Formula
C15H13BrO2
Formula Weight
305.17
MOL File
4254-67-5.mol
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4-(BENZYLOXY)-PHENACYL BROMIDE Property

Melting point:
91 °C
Boiling point:
419.5±25.0 °C(Predicted)
Density 
1.394±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Pale Beige
Stability:
Moisture Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B288010
Product name
1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Packaging
5g
Price
$435
Updated
2021/12/16
AK Scientific
Product number
5878AB
Product name
1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Packaging
250mg
Price
$135
Updated
2021/12/16
Ambeed
Product number
A168007
Product name
1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Purity
98%
Packaging
100mg
Price
$29
Updated
2021/12/16
Ambeed
Product number
A168007
Product name
1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Purity
98%
Packaging
250mg
Price
$58
Updated
2021/12/16
Ambeed
Product number
A168007
Product name
1-(4-(Benzyloxy)phenyl)-2-bromoethanone
Purity
98%
Packaging
1g
Price
$107
Updated
2021/12/16
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4-(BENZYLOXY)-PHENACYL BROMIDE Chemical Properties,Usage,Production

Uses

1-(4-(Benzyloxy)phenyl)-2-bromoethanone is an intermediate of Ractopamine Dimer Ether Dihydrochloride (R071420), which is an impurity of Ractopamine (R071400). A b-Adrenergic agonist. A repartitioning agent.

Preparation

Obtained by reaction of bromine with 4-benzyloxyacetophenone in methanol in the presence of concentrated hydrochloric acid at 0–5° for 1 h, then at r.t. for another 1 h (90%).

Synthesis

54696-05-8

4254-67-5

General procedure for the synthesis of 2-bromo-4'-benzyloxyacetophenone from 1-(4-(benzyloxy)phenyl)ethanone: To a clarified solution of 1-(4-(benzyloxy)phenyl)ethanone (16.1 g, 71.2 mmol) in tetrahydrofuran (200 mL) at 0 °C, slowly add phenyltrimethylammonium tribromide (29.4 g, 78 mmol) dropwise to a tetrahydrofuran ( 150mL) solution. After completion of the reaction, the insoluble material was removed by filtration and washed with tetrahydrofuran. The filtrate was concentrated and the resulting yellow oil was purified by recrystallization from isopropanol. The final product was 2-bromo-4'-benzyloxyacetophenone with a yield of 17.99 g and 83%.

References

[1] Advanced Synthesis and Catalysis, 2018, vol. 360, # 7, p. 1376 - 1383
[2] Journal of the Indian Chemical Society, 2002, vol. 79, # 5, p. 469 - 471
[3] Patent: WO2015/16728, 2015, A1. Location in patent: Page/Page column 36; 37; 62
[4] Australian Journal of Chemistry, 2008, vol. 61, # 12, p. 991 - 999
[5] Marine Drugs, 2012, vol. 10, # 6, p. 1412 - 1421

4-(BENZYLOXY)-PHENACYL BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(BENZYLOXY)-PHENACYL BROMIDE Suppliers

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4254-67-5, 4-(BENZYLOXY)-PHENACYL BROMIDERelated Search:

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline 4-(9-ANTHROYLOXY)PHENACYL BROMIDE 5-BROMOACETYL-2-BENSYLOXYBENZOIC ACID METHYL ESTER 4'-Benzyloxy-2-bromopropiophenone 4-(BENZYLOXY)-PHENACYL BROMIDE 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

  • 4-(BENZYLOXY)-PHENACYL BROMIDE
  • 2-broMo-1-(4-phenylMethoxyphenyl)ethanone
  • 2-Bromo-4'-benzyloxyacetophenon
  • 1-(Bromoacetyl)-4-(benzyloxy)benzene
  • 4'-(Benzyloxy)-α-bromoacetophenone
  • 4'-Benzyloxy-α-bromoacetophenone
  • α-Bromo-4'-(benzyloxy)acetophenone
  • 1-(4-(Benzyloxy)phenyl)-2-bromoethane
  • Ethanone, 2-bromo-1-[4-(phenylmethoxy)phenyl]-
  • 1-(Benzyloxy)-4-(bromoacetyl)benzene
  • 2-bromo-1-(4-benzyloxyphenyl)-1-ethanone
  • 4254-67-5