2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

Product Name: 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
CAS No.: 43229-01-2
Chemical Name: 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
Synonyms: 1-(4-(benzyloxy)-3-nitrophenyl)-2-bromoethan-1-one;1-(4-(BenzyL;)-2-bromoethanone;Formoterol Bromide;oxy)-3-nitrophenyL;Formoterol Impurity 23;Formoterol Impurity 31;Formoterol Intermediate;(phenylmethoxy)phenyl]-ethanone;3-Nitro-4-benzyloxy-2-bromophenone
CBNumber: CB3396148
Molecular Formula: C15H12BrNO4
Formula Weight: 350.16
MOL File: 43229-01-2.mol

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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Property

Melting point:: 135-137 °C(Solv: ethanol (64-17-5))
Boiling point:: 465.2±35.0 °C(Predicted)
Density: 1.517±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in Methylene chloride, sparingly soluble in ethyl acetate, insoluble in water
form: Solid
color: Pale yellow to cream coloured crystalline powder
InChI: InChI=1S/C15H12BrNO4/c16-9-14(18)12-6-7-15(13(8-12)17(19)20)21-10-11-4-2-1-3-5-11/h1-8H,9-10H2
InChIKey: PBAAKBQGBSUCTG-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(OCC2=CC=CC=C2)C([N+]([O-])=O)=C1)CBr
CAS DataBase Reference: 43229-01-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B287165
Product name: 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Packaging: 1g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: J95552
Product name: 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Packaging: 5g
Price: $240
Updated: 2021/12/16

Matrix Scientific

Product number: 090612
Product name: 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Purity: 95+%
Packaging: 250mg
Price: $243
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB61706
Product name: 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Packaging: 10g
Price: $400
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB61706
Product name: 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Packaging: 25g
Price: $500
Updated: 2021/12/16

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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Chemical Properties,Usage,Production

Uses

1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone, can be used as an intermediate in the synthesis of Arformoterol Tartrate (A767505), which is a derivative of Arformoterol, a long acting beta-adrenoceptor agonist drug indicated for the treatment of chronic obstructive pulmonary disease (COPD).

Synthesis

14347-05-8

43229-01-2

Step 2: 200 g of 4-benzyloxy-3-nitroacetophenone (Intermediate 1) was dissolved in 1000 mL of dichloromethane and 277 g of trimethylphenylammonium tribromide was added. The reaction mixture was heated to 300 °C and kept for 4 hours. After completion of the reaction, the residual liquid was poured into water, filtered, washed and dried to give 253 g of 3'-nitro-4'-benzyloxy-2-bromoacetophenone in 98% yield.

References

[1] Patent: CN108358791, 2018, A. Location in patent: Paragraph 0016; 0020
[2] Canadian Journal of Chemistry, 2011, vol. 89, # 3, p. 364 - 384
[3] Chirality, 2010, vol. 22, # 2, p. 206 - 211
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 1, p. 249 - 253
[5] Tetrahedron Asymmetry, 2000, vol. 11, # 13, p. 2705 - 2717

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Suppliers

Canada 1 China 227 Europe 2 Germany 2 India 20 United Kingdom 5 United States 23 Global 280

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View Lastest Price from 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone 43229-01-2
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-09-11

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone 43229-01-2
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-28

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone 43229-01-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-07

43229-01-2, 2-Bromo-4'-Benzyloxy-3'-nitroacetophenoneRelated Search:

PHENYL VALERATE 4-Nitrobenzyl chloroformate 4-Nitrobenzyl alcohol 4'-Bromoacetophenone L-PICEIN 4-Nitroacetophenone 2-Bromoacetophenone 4-Methoxybenzylchloride 3-Nitroacetophenone PHENYL RESIN Phenylacetic acid 3-Nitrophenacylbromide 4-Benzyloxy-3-nitroacetophenone 4-Nitrobenzyl chloride 3-Bromonitrobenzene NITROGEN DIOXIDE 2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE 2'-Bromoacetophenone

ALPHA-BROMO 4-BENZYLOXY-3-NITRO ACETOPHENONE

1-(4-(benzyloxy)-3-nitrophenyl)-2-bromoethan-1-one

Formoterol Bromide

2-Bromo-1-[3-Nitro-4-(Phenylmethoxy)Phenyl]Ethanone

2-Bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]-ethanone

3-BroMo-1-[3-Nitro-4-(PhenylMethoxy)phenyl]Ethanone

Formoterol Intermediate

1-(4-BENZYLOXY-3-NITRO-PHENYL)-2-BROMO-ETHANONE

2-BROMO-4''-BENZYLLOXY-3''-NITROACETOPHENONE

2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanone

Formoterol Impurity 23

1-(4-(BenzyL

oxy)-3-nitrophenyL

Formoterol Impurity 31

Ethanone, 2-bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]-

)-2-bromoethanone

N-(5-((RS)-2-(benzyl((SR)-1-(4-methoxyphenyl)propan-2-yl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide half-fumarate

2-BROMO-3'-NITRO-4'-BENZYLOXY-ACETOPHENONE

4'-Benzyloxy-2-bromo-3'-nitroacetophenone

(phenylmethoxy)phenyl]-ethanone

4-Benzyloxy-3-nitro-alpha-bromoacetophenone

3-Nitro-4-benzyloxy-2-bromophenone

2-bromo-4'-benzyloxy-3'-nitroacetophenone

3'-Nitro-4'-benzyloxy-2-bromobenzophenone

3-Nitro-4-benzyloxy-2-bromoacetophenone

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

2-Bromo-1-[3-nitro-4-(benzyloxy)phenyl]-ethanone

43229-01-2

C15H12BrNO4

Intermediate