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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

Product Name
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
CAS No.
43229-01-2
Chemical Name
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
Synonyms
1-(4-(benzyloxy)-3-nitrophenyl)-2-bromoethan-1-one;1-(4-(BenzyL;)-2-bromoethanone;Formoterol Bromide;oxy)-3-nitrophenyL;Formoterol Impurity 23;Formoterol Impurity 31;Formoterol Intermediate;(phenylmethoxy)phenyl]-ethanone;3-Nitro-4-benzyloxy-2-bromophenone
CBNumber
CB3396148
Molecular Formula
C15H12BrNO4
Formula Weight
350.16
MOL File
43229-01-2.mol
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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Property

Melting point:
135-137 °C(Solv: ethanol (64-17-5))
Boiling point:
465.2±35.0 °C(Predicted)
Density 
1.517±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in Methylene chloride, sparingly soluble in ethyl acetate, insoluble in water
form 
Solid
color 
Pale yellow to cream coloured crystalline powder
InChI
InChI=1S/C15H12BrNO4/c16-9-14(18)12-6-7-15(13(8-12)17(19)20)21-10-11-4-2-1-3-5-11/h1-8H,9-10H2
InChIKey
PBAAKBQGBSUCTG-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC=C(OCC2=CC=CC=C2)C([N+]([O-])=O)=C1)CBr
CAS DataBase Reference
43229-01-2(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B287165
Product name
1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Packaging
1g
Price
$50
Updated
2021/12/16
AK Scientific
Product number
J95552
Product name
1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Packaging
5g
Price
$240
Updated
2021/12/16
Matrix Scientific
Product number
090612
Product name
1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Purity
95+%
Packaging
250mg
Price
$243
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB61706
Product name
1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Packaging
10g
Price
$400
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB61706
Product name
1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone
Packaging
25g
Price
$500
Updated
2021/12/16
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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Chemical Properties,Usage,Production

Uses

1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone, can be used as an intermediate in the synthesis of Arformoterol Tartrate (A767505), which is a derivative of Arformoterol, a long acting beta-adrenoceptor agonist drug indicated for the treatment of chronic obstructive pulmonary disease (COPD).

Synthesis

14347-05-8

43229-01-2

Step 2: 200 g of 4-benzyloxy-3-nitroacetophenone (Intermediate 1) was dissolved in 1000 mL of dichloromethane and 277 g of trimethylphenylammonium tribromide was added. The reaction mixture was heated to 300 °C and kept for 4 hours. After completion of the reaction, the residual liquid was poured into water, filtered, washed and dried to give 253 g of 3'-nitro-4'-benzyloxy-2-bromoacetophenone in 98% yield.

References

[1] Patent: CN108358791, 2018, A. Location in patent: Paragraph 0016; 0020
[2] Canadian Journal of Chemistry, 2011, vol. 89, # 3, p. 364 - 384
[3] Chirality, 2010, vol. 22, # 2, p. 206 - 211
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 1, p. 249 - 253
[5] Tetrahedron Asymmetry, 2000, vol. 11, # 13, p. 2705 - 2717

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Suppliers

Canada 1 China 227 Europe 2 Germany 2 India 20 United Kingdom 5 United States 23 Global 280
Dishman USA, Inc.
Tel
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Fax
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Country
Canada
ProdList
743
Advantage
75
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View Lastest Price from 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone 43229-01-2
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-11
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone 43229-01-2
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-28
Shaanxi Dideu New Materials Co. Ltd
Product
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone 43229-01-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-07

43229-01-2, 2-Bromo-4'-Benzyloxy-3'-nitroacetophenoneRelated Search:

PHENYL VALERATE 4-Nitrobenzyl chloroformate 4-Nitrobenzyl alcohol 4'-Bromoacetophenone L-PICEIN 4-Nitroacetophenone 2-Bromoacetophenone 4-Methoxybenzylchloride 3-Nitroacetophenone PHENYL RESIN Phenylacetic acid 3-Nitrophenacylbromide 4-Benzyloxy-3-nitroacetophenone 4-Nitrobenzyl chloride 3-Bromonitrobenzene NITROGEN DIOXIDE 2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE 2'-Bromoacetophenone

  • ALPHA-BROMO 4-BENZYLOXY-3-NITRO ACETOPHENONE
  • 1-(4-(benzyloxy)-3-nitrophenyl)-2-bromoethan-1-one
  • Formoterol Bromide
  • 2-Bromo-1-[3-Nitro-4-(Phenylmethoxy)Phenyl]Ethanone
  • 2-Bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]-ethanone
  • 3-BroMo-1-[3-Nitro-4-(PhenylMethoxy)phenyl]Ethanone
  • Formoterol Intermediate
  • 1-(4-BENZYLOXY-3-NITRO-PHENYL)-2-BROMO-ETHANONE
  • 2-BROMO-4''-BENZYLLOXY-3''-NITROACETOPHENONE
  • 2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanone
  • Formoterol Impurity 23
  • 1-(4-(BenzyL
  • oxy)-3-nitrophenyL
  • Formoterol Impurity 31
  • Ethanone, 2-bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]-
  • )-2-bromoethanone
  • N-(5-((RS)-2-(benzyl((SR)-1-(4-methoxyphenyl)propan-2-yl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide half-fumarate
  • 2-BROMO-3'-NITRO-4'-BENZYLOXY-ACETOPHENONE
  • 4'-Benzyloxy-2-bromo-3'-nitroacetophenone
  • (phenylmethoxy)phenyl]-ethanone
  • 4-Benzyloxy-3-nitro-alpha-bromoacetophenone
  • 3-Nitro-4-benzyloxy-2-bromophenone
  • 2-bromo-4'-benzyloxy-3'-nitroacetophenone
  • 3'-Nitro-4'-benzyloxy-2-bromobenzophenone
  • 3-Nitro-4-benzyloxy-2-bromoacetophenone
  • 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
  • 2-Bromo-1-[3-nitro-4-(benzyloxy)phenyl]-ethanone
  • 43229-01-2
  • C15H12BrNO4
  • Intermediate