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Ethyl 3,3-Diethoxypropionate

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Ethyl 3,3-Diethoxypropionate Basic information

Product Name:
Ethyl 3,3-Diethoxypropionate
Synonyms:
  • Propanoic acid, 3,3-diethoxy-, ethyl ester
  • 3,3-DIETHOXYPROPIONIC ACID ETHYL ESTER
  • DEPE
  • ETHYL 3,3-DIETHOXYPROPANOATE
  • ETHYL 3,3-DIETHOXYPROPIONATE
  • ETHYL 3,3-DIETHOXYPROPIONATE, TECH., 90%
  • 3,3-Diethoxypropanoic acid, ethyl ester
  • malonaldehydic acid diethyl acetal ethyl ester
CAS:
10601-80-6
MF:
C9H18O4
MW:
190.24
EINECS:
234-223-1
Product Categories:
  • Pyridine
  • Pharmaceutical Intermediates
  • bc0001
Mol File:
10601-80-6.mol
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Ethyl 3,3-Diethoxypropionate Chemical Properties

Melting point:
200-202 °C
Boiling point:
92-93 °C/13 mmHg (lit.)
Density 
0.978 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.411(lit.)
Flash point:
184 °F
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Liquid
color 
Clear colorless
BRN 
1772110
Stability:
Hygroscopic
InChI
InChI=1S/C9H18O4/c1-4-11-8(10)7-9(12-5-2)13-6-3/h9H,4-7H2,1-3H3
InChIKey
SIALOQYKFQEKOG-UHFFFAOYSA-N
SMILES
C(OCC)(=O)CC(OCC)OCC
LogP
2.260 (est)
CAS DataBase Reference
10601-80-6(CAS DataBase Reference)
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Safety Information

Safety Statements 
23-24/25
WGK Germany 
3
10-21
HS Code 
29189900

MSDS

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Ethyl 3,3-Diethoxypropionate Usage And Synthesis

Description

Ethyl 3,3-diethoxypropionate is an organic compound that is synthesized from the reaction of diethyl malonate and chloroacetic acid in the presence of a base catalyst. This product has been shown to be an effective inhibitor of mitochondrial cytochrome c oxidase in vitro studies. Ethyl 3,3-diethoxypropionate also has been found to inhibit quinoline derivatives, such as erythromycin and tetracycline, which are involved in bacterial DNA synthesis. Furthermore, this product inhibits β-unsaturated aldehydes and allylation.

Chemical Properties

clear colorless liquid

Uses

Ethyl 3,3-diethoxypropionate participates in the Yb(OTf)3 catalyzed synthesis of dihydropyridines (DHPs).

Synthesis Reference(s)

The Journal of Organic Chemistry, 47, p. 2216, 1982 DOI: 10.1021/jo00132a055
Synthesis, p. 274, 1988 DOI: 10.1055/s-1988-27541

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