HUMAN IL-7 Chemical Properties

storage temp. 

−20°C

form 

lyophilized powder

color 

white to off-white

biological source

rat

Water Solubility 

water: soluble 0.005-0.010mL

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

HUMAN IL-7 Usage And Synthesis

Biological Activity

IL-7 is a hematopoietic growth factor, which affects primarily early B and T cells. Recombinant r at IL-7 is a 15.0 kDa protein containing 130 amino acid residues.

Description

Interleukin-7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 152 amino acids and having a molecular mass of 17.4 kDa.
The IL-7 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.

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